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Esteban Fernández, Diego ; Moreno Gordaliza, Estefanía ; Cañas, Benito ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | RSC | 2010Pt-containing drugs are nowadays essential components in cancer chemotherapy. However, drug resistance and side effects limit the efficiency of the treatments. In order to improve the response to Pt-based drugs, different administration strategi[...]texto impreso
Camano, Sonia ; Lázaro, Alberto ; Moreno Gordaliza, Estefanía ; Torres, A.M. ; Lucas, Carmen de ; Humanes, Blanca ; Lázaro, José A. ; Gómez Gómez, M.Milagros ; Bosca, Lisardo ; Tejedor, Alberto | American Society for Pharmacology and Experimental Therapeutics | 2010A major area in cancer therapy is the search for protective strategies against cisplatin-induced nephrotoxicity. We investigated the protective effect of cilastatin on cisplatininduced injury to renal proximal tubular cells. Cilastatin is a spec[...]texto impreso
Humanes, Blanca ; Lázaro, Alberto ; Camano, Sonia ; Moreno Gordaliza, Estefanía ; Lázaro, José A. ; Blanco Codesido, Montserrat ; Lara, José M. ; Ortiz, Alberto ; Gómez Gómez, M.Milagros ; Martín Vasallo, Pablo ; Tejedor, Alberto | International Society of Nephrology | 2012Cisplatin is an anticancer agent marred by nephrotoxicity; however, limiting this adverse effect may allow the use of higher doses to improve its efficacy. Cilastatin, a small molecule inhibitor of renal dehydropeptidase I, prevents proximal tub[...]texto impreso
Aboulmagd, Sarah ; Esteban Fernández, Diego ; Moreno Gordaliza, Estefanía ; Neumann, Boris ; El-Khatib, A.H. ; Lázaro, Alberto ; Tejedor, Alberto ; Gómez Gómez, M.Milagros ; Linscheid, Michael W. | ACS | 2017The quest for internal standards useful in MALDI imaging studies goes on to get not only lateral distribution but also reliable relative quantitative information. We developed a method based on application of matrix and dual internal standards t[...]texto impreso
Gómez Gómez, M.Milagros ; Moreno Gordaliza, Estefanía ; Mena Fernández, María Luz ; Palacios Corvillo, M. Antonia ; Cañas Montalvo, Benito | Real Sociedad Española de Química | 2012En este artículo se muestra el potencial que presentan las modernas estrategias bioanalíticas en estudios metalómicos de fármacos de platino. La combinación de técnicas de separación multidimensionales cromatográficas y/o electroforéticas con la[...]texto impreso
El cisplatino es un compuesto antineoplásico que se ha aplicado con éxito desde los años 70 para el tratamiento de numerosos tumores, suponiendo entonces un verdadero hito en quimioterapia, y aún hoy en día empleándose en la mitad de las terapia[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Giesen, Charlotte ; Lehmann, Karola ; Lázaro, Alberto ; Tejedor, Alberto ; Scheler, Christian ; Cañas Montalvo, Benito ; Jakubowski, Norbert ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | RSC | 2012A method for the analysis of Pt–protein complexes in biological samples, previously subjected to cisplatin treatment, has been developed. Proteins were separated by gel electrophoresis, and those bound to Pt were detected with high sensitivity b[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Lázaro, Alberto ; Aboulmagd, Sarah ; Humanes, Blanca ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | American Society for Biochemistry and Molecular Biology Inc. | 2018-07Nephrotoxicity is a major limitation to cisplatin antitumor therapies. Cilastatin, an inhibitor of renal dehydropeptidase-I, was recently proposed as a promising nephroprotector against cisplatin toxicity, preventing apoptotic cell death. In thi[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Lázaro, Alberto ; Humanes, Blanca ; Aboulmagd, Sarah ; Tejedor, Alberto ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | Elsevier | 2017Imaging techniques for mapping molecular distributions in tissue sections can reveal valuable information on biomolecules involved in relevant biochemical processes. A method has been developed for comprehensive, reproducible and sensitive lipid[...]texto impreso
Moreno Gordaliza, Estefanía ; Cañas Montalvo, Benito ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | Royal Society of Chemistry | 2010The characterization of the interaction of platinum drugs with proteins has been previously performed using bottom-up proteomics approaches (enzymatic digestion followed by MS analysis). Nevertheless, the study of the stability of the Pt–protein[...]texto impreso
Mena, María Luz ; Moreno Gordaliza, Estefanía ; Moraleja San José, Irene ; Cañas Montalvo, Benito ; Gómez Gómez, M.Milagros | Elsevier | 2011In this work a 2D electrophoretic separation procedure able to maintain the integrity of platinum–protein bonds has been developed. The method is based on the use of sequential OFFGEL isoelectric focussing (IEF) and PAGE. A systematic study of t[...]texto impreso
Blasco-Benito, Sandra ; Moreno Gordaliza, Estefanía ; Seijo-Vila, Marta ; Tundidor, Isabel ; Andradas Arias, Clara ; Caffarel, María M. ; Caro-Villalobos, Miriam ; Urigüen, Leyre ; Diez-Alarcia, Rebeca ; Moreno-Bueno, Gema ; Hernández, Lucia ; Manso Sánchez, Luis Manuel ; Homar-Ruano, Patricia ; McCormick, Peter J. ; Bibic, Lucka ; Bernadó-Morales, Cristina ; Arribas, Joaquín ; Canals, Meritxell ; Casadó, Vicent ; Canela, Enric I. ; Guzmán, Manuel ; Pérez-Gómez, Eduardo ; Sánchez, Cristina | National Academy of Sciences (USA) | 2019-02-26Although human epidermal growth factor receptor 2 (HER2)- targeted therapies have dramatically improved the clinical outcome of HER2-positive breast cancer patients, innate and acquired resistance remains an important clinical challenge. New the[...]texto impreso
Moraleja, I ; Moreno Gordaliza, Estefanía ; Mena, María Luz ; Gómez Gómez, M.Milagros | Elsevier | 2014The analysis of the complexes between metal-based chemotherapeutic drugs and proteins in biological samples, such as cisplatin or oxaliplatin, can be a challenge due to metal strong reactivity towards S-donor molecules such as dithiothreitol (DT[...]texto impreso
Moreno Gordaliza, Estefanía ; Cañas Montalvo, Benito ; Palacios Corvillo, M. Antonia ; Gómez Gómez, M.Milagros | ACS | 2009The interaction of the antitumor drug cisplatin with insulin was studied using a top-down mass spectrometric approach. In vitro incubations were prepared under acidic and physiological conditions at different insulin/cisplatin molar ratios for d[...]
