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Gómez Gómez, M.Milagros ; Rodríguez Fariñas, Nuria ; Cañas Montalvo, Benito ; Domínguez, Jorge ; Guinovart, Joan ; Cámara Rica, Carmen | Elsevier | 2011-05-30It is known that oral administration of sodium tungstate preserves the pancreatic beta cell function in diabetic rats. Healthy and streptozotocin-induced diabetic rats were treated with sodium tungstate for one, three or six weeks, after which t[...]texto impreso
Gómez Gómez, M.Milagros ; Moreno Gordaliza, Estefanía ; Mena Fernández, María Luz ; Palacios Corvillo, M. Antonia ; Cañas Montalvo, Benito | Real Sociedad Española de Química | 2012En este artículo se muestra el potencial que presentan las modernas estrategias bioanalíticas en estudios metalómicos de fármacos de platino. La combinación de técnicas de separación multidimensionales cromatográficas y/o electroforéticas con la[...]texto impreso
Moreno Gordaliza, Estefanía ; Esteban Fernández, Diego ; Giesen, Charlotte ; Lehmann, Karola ; Lázaro, Alberto ; Tejedor, Alberto ; Scheler, Christian ; Cañas Montalvo, Benito ; Jakubowski, Norbert ; Linscheid, Michael W. ; Gómez Gómez, M.Milagros | RSC | 2012A method for the analysis of Pt–protein complexes in biological samples, previously subjected to cisplatin treatment, has been developed. Proteins were separated by gel electrophoresis, and those bound to Pt were detected with high sensitivity b[...]texto impreso
Moreno Gordaliza, Estefanía ; Cañas Montalvo, Benito ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | Royal Society of Chemistry | 2010The characterization of the interaction of platinum drugs with proteins has been previously performed using bottom-up proteomics approaches (enzymatic digestion followed by MS analysis). Nevertheless, the study of the stability of the Pt–protein[...]texto impreso
Mena, María Luz ; Moreno Gordaliza, Estefanía ; Moraleja San José, Irene ; Cañas Montalvo, Benito ; Gómez Gómez, M.Milagros | Elsevier | 2011In this work a 2D electrophoretic separation procedure able to maintain the integrity of platinum–protein bonds has been developed. The method is based on the use of sequential OFFGEL isoelectric focussing (IEF) and PAGE. A systematic study of t[...]texto impreso
Moreno Gordaliza, Estefanía ; Cañas Montalvo, Benito ; Palacios Corvillo, M. Antonia ; Gómez Gómez, M.Milagros | ACS | 2009The interaction of the antitumor drug cisplatin with insulin was studied using a top-down mass spectrometric approach. In vitro incubations were prepared under acidic and physiological conditions at different insulin/cisplatin molar ratios for d[...]
