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Arroyo, Raquel ; Echaide Torreguitar, Mercedes ; Moreno Herrero, Fernando ; Pérez Gil, Jesús ; Kingma, Paul S. | Elsevier | 2020-04-20Surfactant Protein D (SP-D) is a collectin protein that participates in the innate immune defense of the lungs. SPD mediates the clearance of invading microorganisms by opsonization, aggregation or direct killing, which are lately removed by mac[...]texto impreso
Guagliardo, Roberta ; Merckx, Pieterjan ; Zamborlin, Agata ; Backer, Lynn de ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Smedt, Stefaan C. de ; Raemdonck, Koen | MDPI | 2019-08-23Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by vario[...]texto impreso
Autilio, Chiara ; Echaide Torreguitar, Mercedes ; Benachi, Alexandra ; Marfaing-Koka, Anne ; Capoluongo, Ettore D. ; Pérez-Gil, Jesús ; De Lucca, Daniele | Elsevier | 2017-03Objective: To determine the diagnostic accuracy of the surfactant adsorption test (SAT) as a predictor for the need for surfactant replacement therapy in neonates with respiratory distress syndrome (RDS). Study design Amniotic fluid samples were[...]texto impreso
Echaide Torreguitar, Mercedes ; Autilio, Chiara ; Arroyo, Raquel ; Pérez Gil, Jesús | Elsevier | 2017-09Pulmonary surfactant is a complex of lipids and proteins assembled and secreted by the alveolar epithelium into the thin layer of fluid coating the respiratory surface of lungs. There, surfactant forms interfacial films at the airwater interface[...]texto impreso
Arroyo, Raquel ; Khan, MerajAlam ; Echaide Torreguitar, Mercedes ; Pérez-Gil, Jesús ; Palaniyar, Nades | Nature Research | 2019-12-16An exacerbated amount of neutrophil extracellular traps (NETs) can cause dysfunction of systems during inflammation. However, host proteins and factors that suppress NET formation (NETosis) are not clearly identified. Here we show that an innate[...]texto impreso
López-Rodríguez, Juan C. ; Barderas Manchado, Rodrigo ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Villalba, Mayte ; Batanero Cremades, Eva ; Cruz Rodríguez, Antonio | American Chemical Society | 2016-10-25Aeroallergens are airborne substances?mainly proteins?capable of triggering Th2-immune responses in respiratory allergies. They enter into the body through the upper airways, reaching the mucosa afterward. Mucosae lining at the luminal side cons[...]texto impreso
Surfactant dysfunction during over-expression of TGF-?1 precedes profibrotic lung remodeling in vivo
López Rodríguez, Elena ; Boden, Caroline ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Kolb, Martin ; Gauldie, Jack ; Maus, Ulrich A. ; Ochs, Matthias ; Knudsen, Lars | American Physiological Society | 2016-06Surfactant dysfunction during overexpression of TGF-1 precedes profibrotic lung remodeling in vivo. Am J Physiol Lung Cell Mol Physiol 310: L1260 –L1271, 2016. First published April 22, 2016; doi:10.1152/ajplung.00065.2016.— Transforming growth [...]texto impreso
Autilio, Chiara ; Echaide Torreguitar, Mercedes ; Shankar-Aguilera, Shivani ; Bragado Herrero, Rafael ; Amidani, Davide ; Salomone, Fabrizio ; Pérez-Gil, Jesús ; De Luca, Daniele | American Thoracic Society | 2020-04-20Rationale. No in vivo data are available about the effect of meconium on human surfactant in the early stages of severe meconium aspiration syndrome (MAS). Objectives. To characterize the changes in surfactant composition, function and structure[...]
