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Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Cadena Santoyo, Manuel ; Elvira Hurtado, Lorena ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Ramirez Sebastian, Jose Manuel | Frontiers Media | 2020-09-25Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes degeneration of the lower and upper motor neurons and is the most prevalent motor neuron disease. This disease is characterized by muscle weakness, stiffness, and hyp[...]texto impreso
Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa, de ; García Martín, Elena Salobrar ; Rojas, Pilar ; Fernández Arrabal, José A. ; López Cuenca, Inés ; Rojas López, Blanca ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | IntechOpen | 2018-11The optic nerve (ON) is constituted by the axons of the retinal ganglion cells (RGCs). These axons are distributed in an organized pattern from the soma of the RGC to the lateral geniculated nucleus (where most of the neurons synapse). The key p[...]texto impreso
Fernández Albarral, José Antonio ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | Medknow Publications | 2020-01-28Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressa[...]texto impreso
López Cuenca, Inés ; Hoz Montañana, Rosa de ; García Martín, Elena Salobrar ; Elvira Hurtado, Lorena ; Rojas Lozano, Pilar ; Fernández Albarral, José Antonio ; Barabash, Ana ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-06-03In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 y[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; Hoz Montañana, Rosa de ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Rojas Lozano, Pilar ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | Elsevier | 2020Glaucoma is an age-related neurodegenerative disease that begins at the onset of aging. In this disease, there is an involvement of the immune system and therefore of the microglia. The purpose of this study is to evaluate the microglial activat[...]texto impreso
Fernández Albarral, José Antonio ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, Rosa de ; López Villarín, Nerea ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Licastro, Ester ; Inarejos García, Antonio M. ; Almodóvar, Paula ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | MDPI | 2019-08-22Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs). An increase in the intraocular pressure is the principal risk factor for such loss, but controlling this pressure does not always prevent glaucom[...]texto impreso
García Martín, Elena Salobrar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Rojas Lozano, Pilar ; López Cuenca, Inés ; Fernández Albarral, José Antonio ; Ramirez Sebastian, Jose Manuel | Codon Publications | 2019-12-20The retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed[...]texto impreso
García Martín, Elena Salobrar ; Méndez Hernández, Carmen D. ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; Fernández Arrabal, José A. ; Rojas Lozano, Pilar ; Wang, Surina ; García Feijoo, Julián ; Gil, Pedro ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (A?) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are r[...]texto impreso
Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Cadena Santoyo, Manuel ; Fernández Arrabal, José A. ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Santos García, Irene ; Lago Femia, Eva de ; Urcelay Segura, José Luis ; Ramirez Sebastian, Jose Manuel ; Hoz Montañana, Rosa de ; Salazar Corral, Juan José | MDPI | 2021-02-07The neurodegenerative disease amyotrophic lateral sclerosis (ALS) affects the spinal cord, brain stem, and cerebral cortex. In this pathology, both neurons and glial cells are affected. However, few studies have analyzed retinal microglia in ALS[...]texto impreso
Fernández Arrabal, José A. ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Marco López, Eva María ; Martín Sánchez, Beatriz ; Flores Salguero, Elena ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Barrios Sabador, Vicente ; Avilés Trigueros, Marcelino ; Valiente Soriano, Francisco Javier ; Miralles de Imperial-Ollero, Juan A. ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel ; López Gallardo, Meritxell ; Ramírez Sebastián, Ana Isabel | MDPI | 2021-02-19Signaling mediated by cytokines and chemokines is involved in glaucoma-associated neuroinflammation and in the damage of retinal ganglion cells (RGCs). Using multiplexed immunoassay and immunohistochemical techniques in a glaucoma mouse model at[...]texto impreso
García Martín, Elena Salobrar ; López Cuenca, Inés ; Sánchez Puebla, Lídia ; Hoz Montañana, María Rosa de ; Fernández Arrabal, José A. ; Ramírez Sebastián, Ana Isabel ; Bravo Ferrer, Isbel ; Medina Alonso, Violeta ; Moro Sánchez, María Ángeles ; Saido, Takaomi C. ; Saito, Takashi ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | Frontiers Media | 2021-01-15Background: Alzheimer’s disease (AD) may present retinal changes before brain pathology, suggesting the retina as an accessible biomarker of AD. The present work is a diachronic study using spectral domain optical coherence tomography (SD-OCT) t[...]texto impreso
López Cuenca, Inés ; Hoz Montañana, Rosa de ; García Martín, Elena Salobrar ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Viguera Editores S.L. | 2017-06-01Introducción. El situs inversus del nervio óptico es una anomalía congénita caracterizada por la emergencia de los vasos de la retina en dirección nasal en lugar de temporal. Es causado por una anómala inserción del tallo óptico en la vesícula ó[...]texto impreso
Fernández Arrabal, José A. ; Julián López, Esther, de ; Soler Domínguez, Carmen ; Hoz Montañana, María Rosa de ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Ramirez Sebastian, Jose Manuel ; Pinazo Durán, Mª Dolores ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel | Multidisciplinary Digital Publishing Institute | 2021-02-27Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-relat[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; García Martín, Elena Salobrar ; Salazar Corral, Juan José ; Rojas López, Blanca ; Ajoy, Daniel ; López Cuenca, Inés ; Rojas, Pilar ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Frontiers Media | 2017-07Microglia, the immunocompetent cells of the central nervous system (CNS), act as neuropathology sensors and are neuroprotective under physiological conditions. Microglia react to injury and degeneration with immune-phenotypic and morphological c[...]
