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Llorente Berzal, Álvaro ; Terzian, Ana Luisa B. ; Di Marzo, Vincenzo ; Micale, Vincenzo ; Viveros, María Paz ; Wotjak, Carsten T. | Springer | 2015-08Rationale The contribution of two major endocannabinoids, 2-arachidonoylglycerol (2-AG) and anandamide (AEA), in the regulation of fear expression is still unknown. Objectives We analyzed the role of different players of the endocannabinoid syst[...]texto impreso
Cannabis sativa preparations are among the illicit drugs most commonly used by young people, including pregnant women. The endocannabinoid (eCB) system, which is involved in the regulation of emotional and motivational homeostasis, synaptic plas[...]texto impreso
Background and rationale Polydrug use is a widespread phenomenon, especially among adolescents and young adults. Synthetic cathinones are frequently consumed in combination with other drugs of abuse. However, there is very little information reg[...]texto impreso
Mela Rivas, Virginia ; Jiménez, Sara ; Freire Regatillo, Alejandra ; Barrios, Vicente ; Marco López, Eva ; López Rodríguez, Ana Belén ; Argente, Jesús ; Viveros, María Paz ; Chowen, Julie A. | Elsevier | 2016-12The neonatal leptin surge, occurring from postnatal day (PND) 5 to 13 and peaking at PND9 in rodents, is important for the development of neuroendocrine circuits involved in metabolic control and reproductive function. We previously demonstrated[...]texto impreso
Mela Rivas, Virginia ; Díaz, Francisca ; López Rodríguez, Ana Belén ; Vázquez, María Jesús ; Gertler, Arieh ; Argente, Jesús ; Tena-Sempere, Manuel ; Viveros, María Paz ; Chowen, Julie A. | Oxford University Press | 2015-07Leptin is important in the development of neuroendocrine circuits involved in metabolic control. As both leptin and metabolism influence pubertal development, we hypothesized that early changes in leptin signaling could also modulate hypothalami[...]texto impreso
Gomes, Felipe V. ; Issy, Ana Carolina ; Ferreira, Frederico R. ; Viveros, María Paz ; Del Bel, Elaine A. ; Guimarães, Francisco S. | Oxford University Press | 2015-01-24Background: Preclinical and clinical data suggest that cannabidiol (CBD), a major non-psychotomimetic compound from Cannabis sativa, induces antipsychotic-like effects. However, the antipsychotic properties of repeated CBD treatment have been po[...]texto impreso
López Rodríguez, Ana Belén ; Siopi, Eleni ; Finn, David P. ; Marchand-Leroux, Catherine ; García Segura, Luis Miguel ; Jafarian-Tehrani, Mehrnaz ; Viveros, María Paz | Oxford Open | 2015-01Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal injury, and functional impa[...]texto impreso
López Rodríguez, Ana Belén ; Mela Rivas, Virginia ; Acaz Fonseca, Estefanía ; García Segura, Luis Miguel ; Viveros, María Paz | Elsevier | 2016-05Background and purpose The rates for traumatic brain injury (TBI) have risen in the last decade. Studies in animal models and clinical trials have not yet resulted in an effective treatment for TBI. Leptin, a 16 kDa peptidic hormone is mainly kn[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Viveros, María Paz ; García Segura, Luis Miguel | Public Library of Sciences (PLOS) | 2015-06-03Traumatic brain injury (TBI) incidence rises during adolescence because during this critical neurodevelopmental period some risky behaviors increase. The purpose of this study was to assess the contribution of cannabinoid receptors (CB1 and CB2)[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Giatti, Silvia ; Caruso, Donatella ; Viveros, María Paz ; Melcangi, Roberto C. ; García Segura, Luis Miguel | Elsevier | 2015-06Traumatic brain injury (TBI) is an important cause of disability in humans. Neuroactive steroids, such as progesterone and dehydroepiandrosterone (DHEA), are neuroprotective in TBI models. However in order to design potential neuroprotective str[...]texto impreso
Gomes, Felipe V. ; Llorente de Miguel, Ricardo ; Del Bel, Elaine A. ; Viveros, María Paz ; López Gallardo, Meritxell ; Guimarães, Francisco S. | Elsevier | 2015-05NMDA receptor hypofunction could be involved, in addition to the positive, also to the negative symptoms and cognitive deficits found in schizophrenia patients. An increasing number of data has linked schizophrenia with neuroinflammatory conditi[...]texto impreso
Peñasco, Sara ; Mela Rivas, Virginia ; López Moreno, José Antonio ; Viveros, María Paz | Hindawi Publishing Corporation | 2015In the present study, we aimed to assess the impact of early life stress, in the form of early maternal deprivation (MD, 24 h on postnatal day, pnd, 9), on voluntary alcohol intake in adolescent male and female Wistar rats. During adolescence, f[...]texto impreso
Pavón, Francisco Javier ; Marco López, Eva ; Vázquez, Mariam ; Sánchez, Laura ; Rivera, Patricia ; Gavito, Ana ; Mela Rivas, Virginia ; Alén, Francisco ; Decara, Juan ; Suárez, Juan ; Giné, Elena ; López Moreno, José Antonio ; Chowen, Julie A. ; Rodríguez de Fonseca, Fernando ; Serrano, Antonia ; Viveros, María Paz | Cross Mark | 2016-09-23Intermittent alcohol exposure is a common pattern of alcohol consumption among adolescents and alcohol is known to modulate the expression of the endocannabinoid system (ECS), which is involved in metabolism and inflammation. However, it is unkn[...]texto impreso
López Moreno, José Antonio ; Marcos, Miguel ; Calleja Conde, Javier ; Echeverry-Alzate, Victor ; Buhler, Kora M. ; Costa-Alba, Pilar ; Bernardo, Edgar ; Laso, Francisco Javier ; Rodríguez de Fonseca, Fernando ; Nadal, Rose ; Viveros, María Paz ; Maldonado, Rafael ; Giné Domínguez, Elena | Wiley | 2015-10Background: Alcohol binge drinking is one of the most common patterns of excessive alcohol use and recent data would suggest that histone deacetylases (HDACs) gene expression profiling could be useful as a biomarker for psychiatric disorders. Me[...]texto impreso
Mela Rivas, Virginia ; Díaz, Francisca ; Vázquez, María Jesús ; Argente, Jesús ; Tena Sempere, Manuel ; Viveros, María Paz ; Chowen, Julie A. | Cross Mark | 2016Background: Maternal deprivation (MD) during neonatal life can have long-term effects on metabolism and behavior, with males and females responding differently. We previously reported that MD during 24 h at postnatal day (PND) 9 blocks the phys[...]
