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Valderrama, María José ; González Zorn, Bruno ; Calvo de Pablo, Pilar ; Díez Orejas, Rosalía ; Fernández Acero, Teresa ; Gil-Serna, Jessica ; Juan, Lucía de ; Martín Brieva, Humberto ; Molina Martín, María ; Navarro García, Federico ; Patiño, Belén ; Pla Alonso, Jesús ; Prieto, Daniel ; Rodríguez Fernández, Carmina ; Román González, Elvira ; Sanz Santamaría, Ana Belén ; Silóniz, María Isabel de ; Suárez, Mónica ; Vázquez, Covadonga ; Jiménez Cid, Víctor | Oxford University Press | 2018-09-01The Small World Initiative (SWI) and Tiny Earth are a consolidated and successful education programs rooted in the USA that tackle the antibiotic crisis by a crowdsourcing strategy. Based on active learning, it challenges young students to disco[...]texto impreso
Rodríguez Escudero, Isabel ; Fernández Acero, Teresa ; Cid, Víctor J. ; Molina, María | Nature Research | 2018-05-16The Akt protein kinase is the main transducer of phosphatidylinositol-3,4,5-trisphosphate (PtdIns3,4,5P) signaling in higher eukaryotes, controlling cell growth, motility, proliferation and survival. By co-expression of mammalian class I phospha[...]texto impreso
Coronas Serna, Julia María ; Fernández Acero, Teresa ; Molina, María ; Cid, Víctor J. | Shared Science Publishers | 2018-11-12Phosphatidylinositol 3-kinase (PI3K) is a key regulator of phosphoinositide-dependent signaling in mammalian cells and its dysfunction is related to multiple syndromes, including cancer. By heterologous expression in , we have developed a humani[...]texto impreso
González Rubio, Gema ; Fernández Acero, Teresa ; Martín, Humberto ; Molina Martín, María | MDPI | 2019-04-05Mitogen-activated protein kinases (MAPKs) are key mediators of signaling in fungi, participating in the response to diverse stresses and in developmental processes. Since the precise regulation of MAPKs is fundamental for cell physiology, fungi [...]texto impreso
Mingo, Janire ; Rodríguez Escudero, Isabel ; Luna, Sandra ; Fernández Acero, Teresa ; Amo, Laura ; Jonasson, Amy R ; Zori, Roberto T ; López, José I ; Molina, María ; Cid, Víctor J. ; Pulido, Rafael | Springer Nature | 2018-04-30The PTEN gene encodes a master regulator protein that exerts essential functions both in the cytoplasm and in the nucleus. PTEN is mutated in the germline of both patients with heterogeneous tumor syndromic diseases, categorized as PTEN hamartom[...]texto impreso
Fernández Acero, Teresa ; Rodríguez Escudero, Isabel ; Molina, María ; Cid, Víctor J. | Elsevier | 2015-08-07Phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2] is essential for recognition of the plasma membrane inner leaf by protein complexes. We expressed mammalian class I phosphoinositide 3-kinase (PI3K) in Saccharomyces cerevisiae to eliminate[...]texto impreso
Fernández Acero, Teresa ; Rodríguez Escudero, Isabel ; Vicente, Francisca ; Monteiro, Maria Cândida ; Tormo, José R. ; Cantizani, Juan ; Molina, María ; Cid, Víctor J. | 2012-06-15The phosphatidylinositol 3-kinase (PI3K) pathway couples receptor-mediated signaling to essential cellular functions by generating the lipid second messenger phosphatidylinositol-3,4,5-trisphosphate. This pathway is implicated in multiple aspect[...]texto impreso
Rodríguez Escudero, Isabel ; Fernández Acero, Teresa ; Bravo, Ignacio ; Leslie, Nicholas R. ; Pulido, Rafael ; Molina, María ; Cid, Víctor J. | Elsevier | 2015-05-01The PTEN phosphoinositide 3-phosphatase is a tumor suppressor commonly targeted by pathologic missense mutations. Subject to multiple complex layers of regulation, its capital role in cancer relies on its counteracting function of class I phosph[...]
