Información del autor
Documentos disponibles escritos por este autor (16)
Añadir el resultado a su cesta Hacer una sugerencia Refinar búsqueda
texto impreso
Olombrada, Miriam ; Medina, Pilar ; Budia, Flor ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | De Gruyter | 2016-09Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extr[...]texto impreso
Olombrada, Miriam ; Medina, Pilar ; Budia, Flor ; Gavilanes, José ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | De Gruyter | 2017-01-01Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extrao[...]texto impreso
Olombrada Sacristán, Miriam ; Herrero Galán, Elías ; Tello, Daniel ; Oñaderra Sánchez, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | Elsevier | 2013Fungal ribotoxins were discovered almost 50 years ago as extracellular ribonucleases (RNases) with antitumoral properties. However, the biological function of these toxic proteins has remained elusive. The discovery of the ribotoxin HtA, produce[...]texto impreso
García Ortega, Lucía ; Palacios Ortega, Juan ; Martínez del Pozo, Álvaro | Wiley Online Library | 2018-02-16Fungal ribotoxins constitute a family of extracellular ribonucleases with exquisite specificity against rRNA (ribonucleic acid). They induce apoptotic death of cells after inhibiting protein translation. Ribosomes become functionally incompetent[...]texto impreso
Lacadena, Javier ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Herrero Galán, Elías ; Alegre Cebollada, Jorge ; García Ortega, Lucía ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007RNase T1 is the best known representative of a large family of ribonucleolytic proteins secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among them by their cytotoxic character. They exert their toxic action by[...]texto impreso
Olombrada, Miriam ; Lázaro Gorines, Rodrigo ; López Rodríguez, Juan C. ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Maestro López, Moisés ; Lacadena, Javier ; Gavilanes, José G. ; García Ortega, Lucía | MDPI | 2017Fungi establish a complex network of biological interactions with other organisms in nature. In many cases, these involve the production of toxins for survival or colonization purposes. Among these toxins, ribotoxins stand out as promising candi[...]texto impreso
Álvarez García, Elisa ; García Ortega, Lucía ; De los Ríos, Vivian ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2009Ribonuclease U2, secreted by the smut fungus Ustilago sphaerogena, is a cyclizing ribonuclease that displays a rather unusual specificity within the group of microbial extracellular RNases, best represented by RNase T1. Superposition of the thre[...]texto impreso
Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2015-11Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]texto impreso
Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2016Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]texto impreso
Castaño Rodríguez, Carlos ; Olombrada Sacristán, Miriam ; Partida Hanon, Angélica ; Lacadena García-Gallo, Javier ; Oñaderra Sánchez, Mercedes ; Gavilanes, José G. ; García Ortega, Lucía ; Martínez del Pozo, Álvaro | Elsevier | 2015Ribotoxins are a family of fungal ribosome-inactivating proteins displaying highly specific ribonucleolytic activity against the sarcin/ricin loop (SRL) of the larger rRNA, with a-sarcin as its best-characterized member. Their toxicity arises fr[...]texto impreso
Maestro-López, Moisés ; Olombrada, Miriam ; García Ortega, Lucía ; Serrano González, Daniel ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2017-03-07Fungal ribotoxins are highly specific extracellular RNases which cleave a single phosphodiester bond at the ribosomal sarcin-ricin loop, inhibiting protein biosynthesis by interfering with elongation factors. Most ribotoxins show high degree of [...]texto impreso
Las ribotoxinas son una familia de ribonucleasas, con una característica citotoxicidad y alergenicidad. En esta Tesis Doctoral queda demostrado el papel esencial que un elemento de su estructura, la horquilla amino-terminal, juega en estas funci[...]texto impreso
García Ortega, Lucía ; Alegre Cebollada, Jorge ; García Linares, Sara ; Bruix, Marta ; Martínez del Pozo, Álvaro ; Gavilanes, José G. | Elsevier | 2011-09Actinoporins constitute a group of small and basic ?-pore forming toxins produced by sea anemones. They display high sequence identity and appear as multigene families. They show a singular behaviour at the water-membrane interface: In aqueous s[...]texto impreso
Álvarez García, Elisa ; Diago Navarro, Elizabeth ; Herrero Galán, Elías ; García Ortega, Lucía ; López Villarejo, Juan ; Olmo López, Nieves ; Díaz Orejas, Ramón ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2011Fungal ribotoxins are toxic secreted ribonucleases that cleave a conserved single phosphodiester bond located at the sarcin/ricin loop of the larger rRNA. This cleavage inactivates ribosomes leading to protein biosynthesis inhibition and cell de[...]texto impreso
Olombrada, Miriam ; Peña, Cohue ; Rodríguez Galán, Olga ; Klingauf Nerurkar, Purnima ; Portugal Calisto, Daniela ; Oborská Oplová, Michaela ; Altvater, Martin ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; De la Cruz, Jesús ; García Ortega, Lucía ; Govind Panse, Vikram | Elsevier | 2020-04-04The ribotoxin -sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether -sarcin targets the SRL only[...]
