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Mela Rivas, Virginia ; Hernández, Oskarina ; Hunsche, Caroline ; Díaz, Francisca ; Chowen, Julie A. ; Fuente del Rey, Mónica de la | Elsevier | 2017-10-15The importance of the neonatal leptin surge in rodents in neurodevelopmental processes has aroused curiosity in its implication in other physiological systems. Given the role of leptin in neuro-immune interactions, we hypothesized that the neona[...]texto impreso
Mela Rivas, Virginia ; Jiménez, Sara ; Freire Regatillo, Alejandra ; Barrios, Vicente ; Marco López, Eva ; López Rodríguez, Ana Belén ; Argente, Jesús ; Viveros, María Paz ; Chowen, Julie A. | Elsevier | 2016-12The neonatal leptin surge, occurring from postnatal day (PND) 5 to 13 and peaking at PND9 in rodents, is important for the development of neuroendocrine circuits involved in metabolic control and reproductive function. We previously demonstrated[...]texto impreso
Mela Rivas, Virginia ; Díaz, Francisca ; López Rodríguez, Ana Belén ; Vázquez, María Jesús ; Gertler, Arieh ; Argente, Jesús ; Tena-Sempere, Manuel ; Viveros, María Paz ; Chowen, Julie A. | Oxford University Press | 2015-07Leptin is important in the development of neuroendocrine circuits involved in metabolic control. As both leptin and metabolism influence pubertal development, we hypothesized that early changes in leptin signaling could also modulate hypothalami[...]texto impreso
López Rodríguez, Ana Belén ; Mela Rivas, Virginia ; Acaz Fonseca, Estefanía ; García Segura, Luis Miguel ; Viveros, María Paz | Elsevier | 2016-05Background and purpose The rates for traumatic brain injury (TBI) have risen in the last decade. Studies in animal models and clinical trials have not yet resulted in an effective treatment for TBI. Leptin, a 16 kDa peptidic hormone is mainly kn[...]texto impreso
Peñasco, Sara ; Mela Rivas, Virginia ; López Moreno, José Antonio ; Viveros, María Paz | Hindawi Publishing Corporation | 2015In the present study, we aimed to assess the impact of early life stress, in the form of early maternal deprivation (MD, 24 h on postnatal day, pnd, 9), on voluntary alcohol intake in adolescent male and female Wistar rats. During adolescence, f[...]texto impreso
Pavón, Francisco Javier ; Marco López, Eva ; Vázquez, Mariam ; Sánchez, Laura ; Rivera, Patricia ; Gavito, Ana ; Mela Rivas, Virginia ; Alén, Francisco ; Decara, Juan ; Suárez, Juan ; Giné, Elena ; López Moreno, José Antonio ; Chowen, Julie A. ; Rodríguez de Fonseca, Fernando ; Serrano, Antonia ; Viveros, María Paz | Cross Mark | 2016-09-23Intermittent alcohol exposure is a common pattern of alcohol consumption among adolescents and alcohol is known to modulate the expression of the endocannabinoid system (ECS), which is involved in metabolism and inflammation. However, it is unkn[...]texto impreso
Mela Rivas, Virginia ; Díaz, Francisca ; Vázquez, María Jesús ; Argente, Jesús ; Tena Sempere, Manuel ; Viveros, María Paz ; Chowen, Julie A. | Cross Mark | 2016Background: Maternal deprivation (MD) during neonatal life can have long-term effects on metabolism and behavior, with males and females responding differently. We previously reported that MD during 24 h at postnatal day (PND) 9 blocks the phys[...]texto impreso
Mela Rivas, Virginia ; Díaz, Francisca ; Borcel, Erika ; Argente, Jesús ; Chowen, Julie A. ; Viveros, María Paz | Public Library of Sciences (PLOS) | 2015-09-18Maternal deprivation (MD) during neonatal life has diverse long-term behavioral effects and alters the development of the hippocampus and frontal cortex, with several of these effects being sexually dimorphic. MD animals show a marked reduction [...]texto impreso
En los últimos años, nuestro grupo de investigación ha caracterizado un modelo de estrés neonatal, concretamente un modelo de separación materna (SM) en ratas Wistar durante 24h en el día postnatal (DPN) 9. En el estudio de efectos a corto, medi[...]texto impreso
Mela Rivas, Virginia ; Vargas, Amanda ; Meza, Cecilia ; Kachani, Malika ; Wagner, Edward J. | Elsevier | 2016The appetite suppressant actions of estradiol are due to its ability to attenuate orexigenic signals and potentiate anorexigenic signals. The work from my laboratory has shown that male guinea pigs are more sensitive to the hyperphagic and hypot[...]texto impreso
López Gallardo, Meritxell ; Antón Fernández, A. ; Llorente, R. ; Mela Rivas, Virginia ; Llorente Berzal, Álvaro ; Prada, C. ; Viveros, María Paz | Wiley | 2015-08The present study aimed to better understand the role of the neonatal leptin surge, which peaks on postnatal day (PND)9–10, on the development of the hippocampal formation. Accordingly, male and female rats were administered with a pegylated lep[...]texto impreso
Marco López, Eva María ; Ballesta, Javier Antonio ; Irala, Carlos ; Hernández, María Donina ; Serrano, María Elisa ; Mela Rivas, Virginia ; LópezGallardo, Meritxell ; Viveros, María Paz | Elsevier | 2017-01Alcohol use disorder and depression are highly comorbid, and both conditions exhibit important sexual dimorphisms. Here, we aimed to investigate voluntary alcohol consumption after 6 weeks of chronic mild stress (CMS) in Wistar rats – employed a[...]texto impreso
Marco López, Eva María ; Llorente, Ricardo ; López Gallardo, Meritxell ; Mela Rivas, Virginia ; Llorente Berzal, Álvaro ; Prada, Carmen ; Viveros, María Paz | Elsevier | 2015-04Early life stress, in the form of MD (24 h at pnd 9), interferes with brain developmental trajectories modifying both behavioral and neurobiochemical parameters. MD has been reported to enhance neuroendocrine responses to stress, to affect emoti[...]
