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Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 T cell epitopes and MHCI-peptide lig[...]texto impreso
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Diez Rivero, Carmen ; García Boronat, María ; Reche, Pedro A | Biomedical Informatics Publishing Group | 2008Immunoinformatics is an emerging new field that benefits from computational analyses and tools that facilitate the understanding of the immune system. A large number of immunoinformatics resources such as immune-related databases and analysis so[...]texto impreso
The transport of peptides to the endoplasmic reticulum by the transporter associated with antigen processing (TAP) is a necessary step towards determining CD8 T cell epitopes. In this work, we have studied the predictive performance of support v[...]texto impreso
In this chapter, we show an example of how an epitope database can be integrated to other database resources using the Distributed Annotation System (DAS) (Dowell et al. 2001). For that we describe the TEPIDAS server, a DAS Annotation Server of [...]
