| Título: | Lactoferrin Levels in Tears are Increased by the Topical Application of Diadenosine Tetraphosphate |
| Autores: | Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús |
| Tipo de documento: | texto impreso |
| Editorial: | Taylor & Francis, 2016-09 |
| Dimensiones: | application/pdf |
| Nota general: | info:eu-repo/semantics/restrictedAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias Biomédicas: Medicina: Bioquímica , Materia = Ciencias Biomédicas: Óptica y optometría: Anatomía ocular , Tipo = Artículo |
| Resumen: |
Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples were collected by micropipette and lactoferrin was measured by Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: The concentration of lactoferrin in rabbit tears was significantly increased 1 h after diadenosine tetraphosphate application, remaining elevated for 3 h more. This effect was blocked by P2 receptors antagonists. Conclusions: Topical application of diadenosine tetraphosphate stimulates the secretion of lactoferrin in rabbit tears through P2 receptor activation. |
| En línea: | https://eprints.ucm.es/41803/1/Lactoferrin%20Levels%20in%20Tears%20are%20Increased%20by%20the%20Topical%20Application%20of%20Diadenosine%20Tetraphosphate.pdf |
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