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Título:
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Maleimide and Cyclooctyne-Based Hexakis-Adducts of Fullerene: Multivalent Scaffolds for Copper-Free Click Chemistry on Fullerenes
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Autores:
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Ramos Soriano, Javier ;
Reina, José J. ;
Illescas, Beatriz M. ;
Rojo, Javier ;
Martín, Nazario
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Tipo de documento:
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texto impreso
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Editorial:
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ACS, 2018-01-09
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias: Química: Química orgánica
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Tipo = Artículo
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Resumen:
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The synthesis of multivalent systems based on hexakisadducts of [60]fullerene employing a biocompatible copper-free click chemistry strategy has been accomplished. A symmetric hexakis-adduct of fullerene bearing 12 maleimide units (3) is reported, and it has been employed to carry out the thiol-maleimide Michael addition. To achieve orthogonal click addition, an asymmetric derivative bearing one maleimide and 10 cyclooctynes has been synthesized. The sequential and one-pot transformations of the two clickable groups have been explored, finding the best results in the case of the one-pot experiment. This route has been used to obtain a biocompatible hexakis-adduct appended with two different biomolecules, carbohydrates, and amino acids.
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En línea:
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https://eprints.ucm.es/id/eprint/46622/1/JOC_MS_231117_final%20%28nzario%29.pdf
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