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Muñoz Úbeda, Mónica ; Tolosa Díaz, Andrés ; Bhattacharya, Santanu ; Junquera González, Elena ; Aicart Sospedra, Emilio ; Natale, Paolo ; López-Montero, Iván | American Chemical Society (ACS) | 2019Mitochondria form a dynamic network of constantly dividing and fusing organelles. The balance between these antagonistic processes is crucial for normal cellular function and requires the action of specialized proteins. The mitochondrial membran[...]texto impreso
de la Fuente Herreruela, Diego ; Monnappa, Ajay K. ; Muñoz Úbeda, Mónica ; Morallón Piña, Aarón ; Enciso Rodríguez, Eduardo ; Sánchez Martín, Luis ; Giusti, Fabrice ; Natale, Paolo ; López-Montero, Iván | BMC | 2019Background: The design of efcient drug delivery vectors requires versatile formulations able to simultaneously direct a multitude of molecular targets and to bypass the endosomal recycling pathway of cells. Liposomal-based vectors need the decor[...]texto impreso
La terapia génica es un nuevo campo de la medicina cuyo objetivo es curar una amplia variedad de enfermedades a nivel molecular, o por medio de la substitución de DNA celular dañado o mediante la inserción de genes funcionales en células vivas. [...]texto impreso
Plaza-GA, Ismael ; Manzaneda González, Vanesa ; Kisovec, Matic ; Almendro Vedia, Víctor ; Muñoz Úbeda, Mónica ; Anderluh, Gregor ; Guerrero Martínez, Andrés ; Natale, Paolo ; López-Montero, Iván | BMC | 2019Background: A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest. In nature, the bacterial pa[...]texto impreso
Almendro Vedia, Víctor G. ; García, Carolina ; Ahijado Guzmán, Rubén ; de la Fuente Herreruela, Diego ; Muñoz Úbeda, Mónica ; Natale, Paolo ; Viñas, Montserrat H. ; Albuquerque, Rodrigo Queiroz ; Guerrero Martínez, Andrés ; Monroy, Francisco ; Lillo, M. Pilar ; López-Montero, Iván | Elsevier | 2018Background: The fluorescent dye 10-N-nonyl acridine orange (NAO) is widely used as a mitochondrial marker. NAO was reported to have cytotoxic effects in cultured eukaryotic cells when incubated at high concentrations. Although the biochemical re[...]
