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Muñoz, Juan José ; García Ceca Hernández, Javier ; Montero Herradón, Sara ; Sánchez del Collado, Beatriz ; Alfaro Sánchez, David ; Zapata González, Agustín | Frontiers Media | 2018-04-03For a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), hav[...]texto impreso
Montero Herradón, Sara ; Garcia-Ceca Hernández, Javier ; Sánchez del Collado, Beatriz ; Zapata González, Agustín | 2016-08Thymus development is a complex process in which cell-to-cell interactions between thymocytes and thymic epithelial cells (TECs) are essential to allow a proper maturation of both thymic cell components. Although signals that control thymocyte d[...]texto impreso
García Ceca Hernández, Javier ; Alfaro Sánchez, David ; Montero Herradón, Sara ; Tobajas, Esther ; Muñoz, Juan José ; Zapata González, Agustín | Frontiers Media | 2015-06-26Numerous studies emphasize the relevance of thymocyte–thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes. The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and th[...]texto impreso
Alfaro Sánchez, David ; Garcia Ceca Hernández, José Javier ; Farias de Oliveira, Desio A. ; Terra Granado, Eugenia ; Montero Herradón, Sara ; Cotta de Almeida, Vinicius ; Savino, Wilson ; Zapata González, Agustín | 2015-02Adult thymuses lacking either ephrin type B receptor 2 (EphB2) or EphB3, or expressing a truncated form of EphB2, the forward signal-deficient EphB2LacZ, have low numbers of early thymic progenitors (ETPs) and are colonized in vivo by reduced nu[...]texto impreso
Muñoz, Juan José ; Tobajas, Esther ; Juara, Sonia ; Montero Herradón, Sara ; Zapata González, Agustín Gregorio | Springer | 2019-09-24The mechanisms that determine the commitment of thymic epithelial precursors to the two major thymic epithelial cell lineages, cTECs and mTECs, remain unknown. Here we show that FoxN1 nu mutation, which abolishes thymic epithelium differentiatio[...]texto impreso
Garcia-Ceca Hernández, Javier ; Montero Herradón, Sara ; Alfaro Sánchez, David ; Zapata González, Agustín | Springer Link | 2017-05-24Epithelial-free areas, present in both thymic cortex and medulla, have been studied in WT and EphB-deficient mice that have important alterations in the development of thymic epithelium due to the lack of proper thymocyte–thymic epithelial cell [...]texto impreso
Garcia-Ceca Hernández, Javier ; Montero Herradón, Sara ; Zapata González, Agustín | MDPI | 2020-10-02Intimate interactions between thymic epithelial cells (TECs) and thymocytes (T) have been repeatedly reported as essential for performing intrathymic T-cell education. Nevertheless, it has been described that animals exhibiting defects in these [...]texto impreso
El timo es un órgano linfoide primario responsable del desarrollo funcional de las células T inmunocompetentes. Está compuesto, principalmente, por dos elementos: el epitelio tímico (TEC) y las células linfoides cuyos progenitores colonizan el p[...]
