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Valencia Mahón, Jaris ; Blanco, Belén ; Yañez, Rosa ; Vázquez, Miriam ; Herrero Sánchez, Carmen ; Fernández García, María ; Rodríguez Serrano, Concepción ; Pescador, David ; Blanco, Juan F. ; Hernando Rodríguez, Miriam ; Sánchez Guijo, Fermín ; Lamana, María Luisa ; Segovia, Jose Carlos ; Vicente, Ángeles ; Cañizo, Consuelo del ; Zapata González, Agustín Gregorio | Taylor & Francis | 2016-10Background aims The immunomodulatory properties of mesenchymal stromal cells (MSCs), together with their tissue regenerative potential, make them interesting candidates for clinical application. Methods In the current study, we analyzed the in v[...]texto impreso
Alfaro Sánchez, David ; Rodríguez Sosa, Mariano R. ; Zapata González, Agustín Gregorio | MDPI | 2020-01-22Mesenchymal stromal/stem cells (MSCs) have emerged as important therapeutic agents, owing to their easy isolation and culture, and their remarkable immunomodulatory and anti-inflammatory properties. However, MSCs constitute a heterogeneous cell [...]texto impreso
Numerous epithelia undergo tubulogenesis and branching morphogenesis during their development (i.e., lung, salivary gland, pancreas) in order to establish sufficient available surface for their proper functioning. The thymus is a primary lymphoi[...]texto impreso
Muñoz, Juan José ; Tobajas, Esther ; Juara, Sonia ; Montero Herradón, Sara ; Zapata González, Agustín Gregorio | Springer | 2019-09-24The mechanisms that determine the commitment of thymic epithelial precursors to the two major thymic epithelial cell lineages, cTECs and mTECs, remain unknown. Here we show that FoxN1 nu mutation, which abolishes thymic epithelium differentiatio[...]texto impreso
Entrena Martínez, Ana ; Varas, Alberto ; Vázquez, Miriam ; Melen, Gustavo J. ; Fernández Sevilla, Lidia M. ; García Castro, Javier ; Ramírez, Manuel ; Zapata González, Agustín Gregorio ; Vicente, Ángeles | Elsevier | 2015-07-28Mesenchymal stem cells (MSCs) are key components of the bone marrow microenvironment which contribute to the maintenance of the hematopoietic stem cell niche and exert immunoregulatory functions in innate and adaptive immunity. We analyze the im[...]texto impreso
The thymus is a primary lymphoid organ constituted by a 3D epithelial network that provides a specialized microenvironment in which seeding lymphoid progenitors undergo phenotypical and functional maturation. During the earlier steps of thymic o[...]
