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Título:
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Melatonin synthesis in the human ciliary body triggered by TRPV4 activation: Involvement of AANAT phosphorylation
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Autores:
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Alkozi, Hanan Awad ;
Pérez de Lara, María Jesús ;
Pintor, Jesús
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2017-09
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/restrictedAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias: Química: Bioquímica
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Materia = Ciencias Biomédicas: Óptica y optometría: Anatomía ocular
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Tipo = Artículo
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Resumen:
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Melatonin is a substance synthesized in the pineal gland as well as in other organs. This substance is involved in many ocular functions, giving its synthesis in numerous eye structures. Melatonin is synthesized from serotonin through two enzymes, the first limiting step into the synthesis of melatonin being aralkylamine N-acetyltransferase (AANAT). In this current study, AANAT phosphorylation after the activation of TRPV4 was studied using human non-pigmented epithelial ciliary body cells. Firstly, it was necessary to determine the adequate time and dose of the TRPV4 agonist GSK1016790A to reach the maximal phosphorylation of AANAT. An increase of 72% was observed after 5 min incubation with 10 nM GSK (**p
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En línea:
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https://eprints.ucm.es/45086/1/Pintor_melatonin%20synthesis-ExperimentalEyeResearch-Elsevier-2017.pdf
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