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Olombrada, Miriam ; Medina, Pilar ; Budia, Flor ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | De Gruyter | 2016-09Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extr[...]texto impreso
Olombrada, Miriam ; Medina, Pilar ; Budia, Flor ; Gavilanes, José ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | De Gruyter | 2017-01-01Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extrao[...]texto impreso
Olombrada, Miriam ; Lázaro Gorines, Rodrigo ; López Rodríguez, Juan C. ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Maestro López, Moisés ; Lacadena, Javier ; Gavilanes, José G. ; García Ortega, Lucía | MDPI | 2017Fungi establish a complex network of biological interactions with other organisms in nature. In many cases, these involve the production of toxins for survival or colonization purposes. Among these toxins, ribotoxins stand out as promising candi[...]texto impreso
Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2015-11Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]texto impreso
Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2016Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]texto impreso
Maestro-López, Moisés ; Olombrada, Miriam ; García Ortega, Lucía ; Serrano González, Daniel ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2017-03-07Fungal ribotoxins are highly specific extracellular RNases which cleave a single phosphodiester bond at the ribosomal sarcin-ricin loop, inhibiting protein biosynthesis by interfering with elongation factors. Most ribotoxins show high degree of [...]texto impreso
Olombrada, Miriam ; Peña, Cohue ; Rodríguez Galán, Olga ; Klingauf Nerurkar, Purnima ; Portugal Calisto, Daniela ; Oborská Oplová, Michaela ; Altvater, Martin ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; De la Cruz, Jesús ; García Ortega, Lucía ; Govind Panse, Vikram | Elsevier | 2020-04-04The ribotoxin -sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether -sarcin targets the SRL only[...]texto impreso
Olombrada, Miriam ; Peña, Cohue ; Rodríguez Galán, Olga ; Klingauf Nerurkar, Purnima ; Portugal Calisto, Daniela ; Oborská Oplová, Michaela ; Altvater, Martin ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Cruz, Jesús de la ; García Ortega, Lucía ; Govind Panse, Vikram | Oxford University Press | 2020The ribotoxin -sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether -sarcin targets the SRL only[...]
