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Jones, T.D. ; Hearn, A.R. ; Holgate, R.G. ; Kozub, D. ; Fogg, M.H. ; Carr, F.J. ; Baker, M.P. ; Lacadena, Javier ; Gehlsen, K.R. | Oxford University Press | 2016-08-29Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. ?-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single [...]texto impreso
Lázaro Gorines, Rodrigo ; López Rodríguez, Juan Carlos ; Benedé, Sara ; González, Miguel ; Mayorga, Cristobalina ; Vogel, Lothar ; Martínez del Pozo, Álvaro ; Lacadena, Javier ; Villalba, Mayte | Nature Research | 2020-07-23Immunotoxins appear as promising therapeutic molecules, alternative to allergen-specifcimmunotherapy. In this work, we achieved the development of a protein chimera able to promote specifc cell death on efector cells involved in the allergic rea[...]texto impreso
Tomé Amat, Jaime ; Olombrada Sacristán, Miriam ; Ruiz de la Herrán, Javier ; Pérez Gómez, Eduardo ; Andradas Arias, Clara ; Sánchez García, Cristina ; Martínez, Leopoldo ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Elsevier | 2015-04Tagging of RNases, such as the ribotoxin ?-sarcin, with the variable domains of antibodies directed to surface antigens that are selectively expressed on tumor cells endows cellular specificity to their cytotoxic action. A recombinant single-cha[...]texto impreso
Lacadena, Javier ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Herrero Galán, Elías ; Alegre Cebollada, Jorge ; García Ortega, Lucía ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007RNase T1 is the best known representative of a large family of ribonucleolytic proteins secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among them by their cytotoxic character. They exert their toxic action by[...]texto impreso
Olombrada, Miriam ; Lázaro Gorines, Rodrigo ; López Rodríguez, Juan C. ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Maestro López, Moisés ; Lacadena, Javier ; Gavilanes, José G. ; García Ortega, Lucía | MDPI | 2017Fungi establish a complex network of biological interactions with other organisms in nature. In many cases, these involve the production of toxins for survival or colonization purposes. Among these toxins, ribotoxins stand out as promising candi[...]texto impreso
Herrero Galán, Elías ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Gavilanes, José G. | Caister Academic Press | 2009Ribotoxins are a family of fungal extracellular ribonucleases which inactivate ribosomes by specifically cleaving a single phosphodiester bond located at the universally conserved sarcin/ricin loop of the large rRNA. The subsequent inhibition of[...]texto impreso
Ruiz-de-la-Herrán, Javier ; Tomé-Amat, Jaime ; Lázaro Gorines, Rodrigo ; Gavilanes, José G. ; Lacadena, Javier | MDPI | 2019-10-12Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among them, RNases-based immun[...]texto impreso
Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2015-11Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]texto impreso
Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2016Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]texto impreso
Maestro-López, Moisés ; Olombrada, Miriam ; García Ortega, Lucía ; Serrano González, Daniel ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2017-03-07Fungal ribotoxins are highly specific extracellular RNases which cleave a single phosphodiester bond at the ribosomal sarcin-ricin loop, inhibiting protein biosynthesis by interfering with elongation factors. Most ribotoxins show high degree of [...]texto impreso
Tomé-Amat, Jaime ; Herrero-Galán, Elías ; Oñaderra, Mercedes ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Wiley | 2015-06Immunotoxins are chimeric proteins composed of an antibody domain that specifically directs the action of the toxic domain, resulting in the death of the targeted cells. Over recent years, immunotoxins have been widely studied and the number of [...]texto impreso
Tomé-Amat, Jaime ; Ruiz de la Herrán, Javier ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Wiley | 2015-04Toxins have been thoroughly studied for their use as therapeutic agents in search of an improvement in toxic efficiency together with a minimization of their undesired side effects. Different studies have shown how toxins can follow different in[...]texto impreso
Rivera de Torre, Esperanza ; García Linares, Sara ; Alegre Cebollada, Jorge ; Lacadena, Javier ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | American Society for Biochemistry and Molecular Biology | 2016-04-27Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are pore forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes. Intriguingly, actinoporins appear as multigene[...]texto impreso
Rivera de la Torre, Esperanza ; García Linares, Sara ; Alegre Cebollada, Jorge ; Lacadena, Javier ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | ASBMB American Society for Biochemistry and Molecular Biology | 2016Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are the pore-forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes. Intriguingly, actinoporins appear as multi[...]texto impreso
Carreras Sangrà, Nelson ; Álvarez García, Elisa ; Herrero Galán, Elías ; Tomé, Jaime ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Bentham Science Publishers Ltd. | 2008Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin–ricin loop. This cleavage of a single phosphodiester bond inactiv[...]
