| Título: | Magnetoencephalographic parietal ? dipole density in mild cognitive impairment: Preliminary results of a method to estimate the risk of developing Alzheimer disease |
| Autores: | Fernández, Alberto ; Turrero, Agustín ; Zuluaga Arias, Pilar ; Gil, Pedro ; Maestú, Fernando ; Campo, Pablo ; Ortiz, Tomás |
| Tipo de documento: | texto impreso |
| Editorial: | American Medical Association, 2006-03 |
| Palabras clave: | Estado = Publicado , Materia = Ciencias: Matemáticas: Estadística aplicada , Materia = Ciencias Biomédicas: Biología , Tipo = Artículo |
| Resumen: |
Background: Subjects with mild cognitive impairment (MCI) are at a higher risk of experiencing Alzheimer disease (AD). Magnetoencephalographic temporoparietal dipole densities of low-frequency activity are good predictors of individuals' cognitive status, and might be a useful tool to investigate the conversion from MCI to AD. Objective: To investigate the role of low-frequency dipole densities as predictors of the risk of developing AD. Design: Whole-head magnetoencephalographic recordings were obtained from 19 probable AD patients, 17 MCI patients, and 17 healthy control subjects. The generators of focal magnetic slow waves were located using a single moving dipole model. Results: Left parietal ? dipole density permitted a reliable classification of AD and MCI patients. The MCI patients were divided into 2 groups based on the median left parietal ? dipole density, and were followed up for 2 years. The estimated relative risk of conversion to AD was increased by 350% in those MCI patients with high left parietal ? dipole density scores. Conclusions: Results confirmed the important role of parietal ? dipole density in the evaluation of AD and MCI. A magnetoencephalographic-based assessment of AD and MCI patients might be considered a useful clinical test in the near future. |
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