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Ruiz Calvo, Andrea ; Bajo-Grañeras, Raquel ; Maroto, Irene B. ; Zian, Debora ; Grabner, Gernot F. ; García-Taboada, Elena ; Resel, Eva ; Zechner, Rudolf ; Zimmermann, Robert ; Ortega-Gutiérrez, Silvia ; Galve Roperh, Ismael ; Bellocchio, Luigi ; Guzmán, Manuel | Elsevier | 2019-05-15Cannabinoids exert neuroprotection in a wide array of preclinical models. A number of these studies has focused on cannabinoid CB1 receptors in striatal medium spiny neurons (MSNs) and the most characteristic MSN-degenerative disease, Huntington[...]texto impreso
Bravo Ferrer, Isbel ; Cuartero Desviat, María Isabel ; Zarruk, Juan G. ; Pradillo, Jesús M. ; Hurtado Moreno, Olivia ; Romera, Victor G. ; Díaz Alonso, Javier ; García Segura, Juan Manuel ; Guzmán, Manuel ; Lizasoaín, Ignacio ; Galve Roperh, Ismael ; Moro, María A. | American Heart Association | 2017-01Background and Purpose—Stroke is a leading cause of adult disability characterized by physical, cognitive, and emotional disturbances. Unfortunately, pharmacological options are scarce. The cannabinoid type-2 receptor (CB2R) is neuroprotective i[...]texto impreso
Díaz Alonso, Javier ; Aguado, Tania ; Salas Quiroga, Adán de ; Ortega, Zaira ; Guzmán, Manuel ; Galve Roperh, Ismael | Oxford University Press | 2015-09The CB1 cannabinoid receptor regulates cortical progenitor proliferation during embryonic development, but the molecular mechanism of this action remains unknown. Here, we report that CB1-deficient mouse embryos show premature cell cycle exit, d[...]texto impreso
García Rincón, Daniel ; Díaz Alonso, Javier ; Paraíso Luna, Juan ; Otega, Zaira ; Aguareles, José ; Salas Quiroga, Adán de ; Jou, Cristina ; Prada, Inmaculada de ; Martínez Cerdeño, Verónica ; Aronica, Eleonora ; Guzmán, Manuel ; Pérez-Jiménez, María Ángeles ; Galve Roperh, Ismael | Frontiers Media | 2019-01Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly an[...]texto impreso
Blázquez Ortiz, Cristina ; Ruiz-Calvo, Andrea ; Bajo-Grañeras, Raquel ; Baufreton, Jérôme M. ; Resel, Eva ; Varilh, Marjorie ; Pagano Zottola, Antonio C. ; Mariani, Yamuna ; Cannich, Astrid ; Rodríguez-Navarro, José A. ; Marsicano, Giovanni ; Galve Roperh, Ismael ; Bellocchio, Luigi ; Guzmán Pastor, Manuel | eLife Sciences Publications | 2020-08-10The use of cannabis is rapidly expanding worldwide. Thus, innovative studies aimed to identify, understand and potentially reduce cannabis-evoked harms are warranted. Here, we found that D 9 -tetrahydrocannabinol, the psychoactive ingredient of [...]texto impreso
Aguareles, José ; Paraíso Luna, Juan ; Palomares, Belén ; Bajo-Grañeras, Raquel ; Navarrete, Carmen ; Ruiz-Calvo, Andrea ; García Rincón, Daniel ; García-Taboada, Elena ; Guzmán, Manuel ; Muñoz, Eduardo ; Galve Roperh, Ismael | BMC | 2019-03-08Background: The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated by C[...]texto impreso
Salas Quiroga, Adán de ; Díaz Alonso, Javier ; García-Rincón, Daniel ; Remmers, Floortje ; Vega, David ; Gómez Cañas, María ; Lutz, Beat ; Guzmán, Manuel ; Galve Roperh, Ismael | National Academy of Sciences | 2015-11The CB1 cannabinoid receptor, the main target of ?9 -tetrahydrocannabinol (THC), the most prominent psychoactive compound of marijuana, plays a crucial regulatory role in brain development as evidenced by the neurodevelopmental consequences of i[...]
