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Gil Bona, Ana ; Parra Giraldo, Claudia Marcela ; Hernaez, Maria Luisa ; Reales Calderón, José Antonio ; Solis, Norma V. ; Filler, Scott G. ; Monteoliva Díaz, Lucía ; Gil, Concha | Elsevier | 2015-09-08The ability to switch from yeast to hyphal growth is essential for virulence in Candida albicans. The cell surface is the initial point of contact between the fungus and the host. In this work, a free-gel proteomic strategy based on tryptic dige[...]texto impreso
Reales Calderón, José Antonio ; Sylvester, Marc ; Strijbis, Karin ; Jensen, Ole N. ; Nombela, César ; Molero, Gloria ; Gil, Concha | Elsevier | 2013-07-05Macrophages play a pivotal role in the prevention of Candida albicans infections. Yeast recognition and phagocytosis by macrophages is mediated by Pattern Recognition Receptors (PRRs) that initiate downstream signal transduction cascades by prot[...]texto impreso
Reales Calderón, José Antonio ; Vaz, Catarina ; Monteoliva Díaz, Lucía ; Molero, Gloria ; Gil, Concha | American Chemical Society | 2016-10-14The effectiveness of macrophages in the response to systemic candidiasis is crucial to an effective clearance of the pathogen. The secretion of proteins, mRNAs, non-coding RNAs and lipids through extracellular vesicles (EVs) is one of the mechan[...]texto impreso
Vialás, Vital ; Sun, Zhi ; Loureiro yPenha, Carla Verónica ; Carrascal, Montserrat ; Abian, J. ; Monteoliva Díaz, Lucía ; Deutsch, Eric W. ; Aebersold, Ruedi ; Moritz, Robert L. ; Gil, Concha | Elsevier | 2014Candida albicans public proteomic datasets, though growing steadily in the last few years, still have a very limited presence in online repositories. We report here the creation of a C. albicans PeptideAtlas comprising near 22,000 distinct pepti[...]texto impreso
Vialás, Vital ; Perumal, Palani ; Gutierrez, Dolores ; Ximénez-Embún, Pilar ; Nombela, César ; Gil, Concha ; Chaffin, W. LaJean | http://onlinelibrary.wiley.com/doi/10.1002/pmic.201100588/abstract | 2012-08We used a brief trypsin treatment followed by peptide separation and identification using nano-LC followed by off-line MS/MS to identify the surface proteins on live Candida albicans organisms growing in biofilms and planktonic yeast cells and h[...]texto impreso
Buján, Noemí ; Hernández Haro, Carolina ; Monteoliva Díaz, Lucía ; Gil, Concha ; Magariños, Beatriz | Elsevier | 2015-09-08Edwardsiella tarda is an enteric opportunistic pathogen that causes a great loss in aquaculture. This species has been described as a phenotypical homogeneous group; in contrast, serological studies and molecular typing revealed a wide heterogen[...]texto impreso
Invasive Candidiasis (IC) poses a major public health problem worldwide. Despite the introduction of new antifungal agents and changes in clinical practices, its morbidity and mortality rates and healthcare costs remain persistently high. This i[...]texto impreso
Kubitschek-Barreira, Paula H. ; Curty, Nathalia ; Neves, Gabriela W. P. ; Gil, Concha ; Lopes-Bezerra, Leila M. | Elsevier | 2013-01Aspergillus fumigatus is the main etiological agent of invasive aspergillosis, an important opportunistic infection for neutropenic patients. The main risk groups are patients with acute leukemia and bone marrow transplantation recipients. The l[...]texto impreso
Baro, Bárbara ; Rodríguez Rodríguez, José Antonio ; Calabria, Inés ; Hernáez Sánchez, Maria Luisa ; Gil, Concha ; Queralt, Ethel | 2013Exit from mitosis in budding yeast is triggered by activation of the key mitotic phosphatase Cdc14. At anaphase onset, the protease separase and Zds1 promote the downregulation of PP2A(Cdc55) phosphatase, which facilitates Cdk1-dependent phospho[...]texto impreso
Navarro, Pedro ; Trevisan Herraz, Marco ; Bonzon Kulichenko, Elena ; Núñez, Estefanía ; Martínez Acedo, Pablo ; Pérez Hernández, Daniel ; Jorge, Inmaculada ; Mesa, Raquel ; Calvo, Enrique ; Carrascal, Montserrat ; Hernaez, Maria Luisa ; García, Fernando ; Bárcena, José Antonio ; Ashman, Keith ; Abian, J. ; Gil, Concha ; Redondo, Juan Miguel ; Vázquez, Jesús | American Chemical Society | 2014-01-31The combination of stable isotope labeling (SIL) with mass spectrometry (MS) allows comparison of the abundance of thousands of proteins in complex mixtures. However, interpretation of the large data sets generated by these techniques remains a [...]texto impreso
Clemente, Luis Felipe ; Hernaez, Maria Luisa ; Ramos-Fernández, Antonio ; Ligero, Gertrudis ; Gil, Concha ; Corrales, Fernando José ; Marcilla, Miguel | American Chemical Society | 2018-07-05Currently, 14% of the human proteome is made up of proteins whose existence is not confirmed by mass spectrometry. We performed a proteomic profiling of human mesenchymal stem cells derived from adipose tissue or umbilical cord (PRIDE accession [...]texto impreso
Martínez Martínez, Sonia ; Frandoloso, Rafael ; Rodríguez Ferri, Elías F. ; Gil, Concha ; Hernández Haro, Carolina ; Yubero, Sheila ; Gutiérrez Martín, César B. | Elsevier | 2013-02An immunoproteomic analysis of the protective response of subunit and commercial vaccines in colostrum-deprived pigs against Glässer's disease was carried out. A mixture of proteins with affinity to porcine transferrin (PAPT) from Haemophilus pa[...]texto impreso
Hernández Haro, Carolina ; Llopis, Silvia ; Molina, María ; Monteoliva Díaz, Lucía ; Gil, Concha | Elsevier | 2015-01-01Saccharomyces cerevisiae is considered a safe microorganism widely used as a dietary supplement. However, in the latest decades several cases of S. cerevisiae infections have been reported. Recent studies in a murine model of systemic infection [...]texto impreso
Faria Oliveira, Fábio ; Carvalho, Joana ; Belmiro, Celso LR ; Martinez Gomariz, Montserrat ; Hernaez, Maria Luisa ; Pavão, Mauro ; Gil, Concha ; Lucas, Cândida ; Ferreira, Célia | BioMed Central | 2014BACKGROUND In a multicellular organism, the extracellular matrix (ECM) provides a cell-supporting scaffold and helps maintaining the biophysical integrity of tissues and organs. At the same time it plays crucial roles in cellular communication [...]texto impreso
Pinto, Luís ; Torres, Carmen ; Gil, Concha ; Nunes-Miranda, Júlio D ; Santos, Hugo M ; Borges, Vítor ; Gomes, João P ; Silva, Catarina ; Vieira, Luís ; Pereira, José E ; Poeta, Patrícia ; Igrejas, Gilberto | Frontiers Media | 2019-05-03Extended-spectrum beta-lactamase (ESBL)-producing strain C999 was isolated of a Spanish patient with urinary tract infection. Previous genotyping indicated that this strain presented a multidrug-resistance phenotype and carried beta-lactamase g[...]
