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Paris, J.L. ; Villaverde, Gonzalo ; Cabañas Criado, Maria Victoria ; Manzano García, Miguel ; Vallet Regí, María | Royal Society of Chemistry | 2018-04-11In this work we present the synthesis, characterization and in vitro biological evaluation of PEGylated and actively-targeted ultrasound-responsive hybrid mesoporous silica nanoparticles. This work covers the development of the chemical strategi[...]texto impreso
Lopez, Victoria ; Villegas, Maria Rocio ; Rodriguez, Veronica ; Villaverde, Gonzalo ; Lozano, Daniel ; Baeza, Alejandro ; Vallet Regí, María | ACS | 2017-07-31The development of targeted nanocarriers able to be selectively internalized within tumor cells, and therefore to deliver anti-tumor drugs specifically to diseased cells, constitutes one of the most important goals in nano-oncology. Herein, the [...]texto impreso
Villaverde, Gonzalo ; Alfranca, Arantzazú ; González-Murillo, África ; Melen, Gustavo J. ; Castillo, Rafael R. ; Ramírez, Manuel ; Baeza, Alejandro ; Vallet Regí, María | Wiley-VCH | 2018-12-10The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as some of the most important challenges in nanomedicine field. The cellular selectivity of nanocarriers is usually achieved by their surface decoratio[...]texto impreso
Paris, J.L. ; Villaverde, Gonzalo ; Gómez-Graña, Sergio ; Vallet Regí, María | Elsevier | 2019-11-06The poor delivery of nanoparticles to target cancer cells hinders their success in the clinical setting. In this work, an alternative target readily available for circulating nanoparticles has been selected to eliminate the need for nanoparticle[...]texto impreso
Villaverde, Gonzalo ; Baeza, Alejandro ; Melen, Gustavo J. ; Alfranca, Arantzazú ; Ramírez, Manuel ; Vallet Regí, María | Royal Society of Chemistry | 2015-04-14Novel targeting agents against neuroblastoma based on the meta-iodobenzylguanidine (MIBG) moiety were synthesized and biologically evaluated for nanocarrier vectorization. These compounds have been anchored on the surface of drug loaded mesoporo[...]texto impreso
Villaverde, Gonzalo ; Gómez-Graña, Sergio ; Guisasola, Eduardo ; García, Isabel ; Hanske, Cristoph ; Liz-Marzan, Luis M ; Baeza, Alejandro ; Vallet Regí, María | Wiley-VCH Verlag GmbH | 2018Melanoma is one of the most severe public health issues worldwide, not onlybecause of the high number of cases but also for its poor prognosis in late stages. Therefore, early diagnosis and efficient treatment are key toward a future solution. H[...]
