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Introduction: Nanocarriers have emerged as a powerful alternative for cancer therapy.Indeed, they are promising candidates to tackle the acquired resistance of surviving cells against antiproliferative drugs – the so-called multidrug resistance [...]texto impreso
Baeza García, Alejandro ; Castillo Romero, Rafael ; Torres Pardo, Almudena ; Gonzalez Calvet, J. M. ; Vallet Regí, María | Royal Society of Chemistry | 2017-02-17The use of nanoparticles able to transport drugs, in a selective and controlable manner, directly to diseased tissues and cells have improved the therapeutic arsenal for addressing unmet clinical situations. In the recent years, a vast number of[...]texto impreso
Combination therapy has emerged as one of the most promising approaches for cancer treatment. However, beyond remotely-triggered therapies that require advanced infrastructures and optimization, new combination therapies based on internally trig[...]texto impreso
Castillo Romero, Rafael ; Torre, Lorena de la ; García Ochoa, Félix ; Ladero Galán, Miguel ; Vallet Regí, María | MDPI | 2020-10-24The synthesis of MCM-41mesoporous silica nanoparticles (MSNs) of controlled sizes and porous structure has been performed at laboratory and pilot plant scales. Firstly, the effects of the main operating conditions (TEOS addition rate, nanopartic[...]texto impreso
Castillo Romero, Rafael ; Baeza, Alejandro ; Vallet Regí, María | Royal Society of Chemistry | 2017-01-20The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Much is the importance of those gene-keeping biomacromolecules that eve[...]texto impreso
Castillo Romero, Rafael ; Hernández-Escobar, David ; Gómez Graña, Sergio ; Vallet Regí, María | Wiley | 2018-03-02The implementation of nanoparticles as nanomedicines require from sophisticated surface modifications in order to reduce immune response and enhance recognition abilities. In addition to that, Mesoporous Silica nanoparticles present extraordinar[...]
