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Camano, Sonia ; Lázaro, Alberto ; Moreno Gordaliza, Estefanía ; Torres, A.M. ; Lucas, Carmen de ; Humanes, Blanca ; Lázaro, José A. ; Gómez Gómez, M.Milagros ; Bosca, Lisardo ; Tejedor, Alberto | American Society for Pharmacology and Experimental Therapeutics | 2010A major area in cancer therapy is the search for protective strategies against cisplatin-induced nephrotoxicity. We investigated the protective effect of cilastatin on cisplatininduced injury to renal proximal tubular cells. Cilastatin is a spec[...]texto impreso
Humanes, Blanca ; Lázaro, Alberto ; Camano, Sonia ; Moreno Gordaliza, Estefanía ; Lázaro, José A. ; Blanco Codesido, Montserrat ; Lara, José M. ; Ortiz, Alberto ; Gómez Gómez, M.Milagros ; Martín Vasallo, Pablo ; Tejedor, Alberto | International Society of Nephrology | 2012Cisplatin is an anticancer agent marred by nephrotoxicity; however, limiting this adverse effect may allow the use of higher doses to improve its efficacy. Cilastatin, a small molecule inhibitor of renal dehydropeptidase I, prevents proximal tub[...]
