| Título: | Tear Secretion Induced by Selective Stimulation of Corneal and Conjunctival Sensory Nerve Fibers |
| Autores: | Acosta Boj, Mª Carmen ; Peral Cerdá, Assumpta ; Luna García, Carolina ; Pintor, Jesús ; Belmonte, Carlos ; Gallar Martínez, Juana |
| Tipo de documento: | texto impreso |
| Editorial: | The Association for Research in Vision and Ophthalmology, Inc., 2004-07 |
| Dimensiones: | application/pdf |
| Nota general: |
cc_by_nc_nd info:eu-repo/semantics/openAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias: Química: Bioquímica , Materia = Ciencias Biomédicas: Medicina: Neurociencias , Materia = Ciencias Biomédicas: Medicina: Oftalmología , Tipo = Artículo |
| Resumen: |
Purpose. To measure the increase in tear secretion evoked by selective stimulation of the different populations of sensory receptors of the cornea and conjunctiva by using moderate and intense mechanical, chemical, and cold stimuli. Methods. Six healthy subjects participated in the study. Tear secretion was measured in both eyes by the Schirmer’s test conducted under control conditions and after stimulation of the center of the cornea and the temporal conjunctiva with a gas esthesiometer. Mechanical stimulation consisted in three pulses of 3 seconds’ duration of warmed air (at 34°C on the eye surface) applied at moderate (170 mL/min) and high (260 mL/min) flow rates. Cold thermal stimulation was made with cooled air that produced a corneal temperature drop of ?1°C or ?4.5°C. Chemical (acidic) stimulation was performed with a jet of gas containing a mixture of 80% CO2 in air. Results. The basal volume of tear secretion increased significantly (P Conclusions. Reflex tear secretion caused by corneal stimulation seems to be chiefly due to activation of corneal polymodal nociceptors, whereas selective excitation of corneal mechanonociceptors or cold receptors appears to be less effective in evoking an augmented lacrimal secretion. Conjunctival receptors stimulated at equivalent levels do not evoke an increased tear secretion. |
| En línea: | https://eprints.ucm.es/39565/1/Tear%20secretion_IOVS_2004.pdf |
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