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Alegre Cebollada, Jorge ; Cunietti, Michela ; Herrero Galán, Elías ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2008-08The mechanisms by which pore-forming toxins are able to insert into lipid membranes are a subject of the highest interest in the field of lipid–protein interaction. Eight mutants affecting different regions of sticholysin II, a member of the por[...]texto impreso
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Olombrada Sacristán, Miriam ; Herrero Galán, Elías ; Tello, Daniel ; Oñaderra Sánchez, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | Elsevier | 2013Fungal ribotoxins were discovered almost 50 years ago as extracellular ribonucleases (RNases) with antitumoral properties. However, the biological function of these toxic proteins has remained elusive. The discovery of the ribotoxin HtA, produce[...]texto impreso
Lacadena, Javier ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Herrero Galán, Elías ; Alegre Cebollada, Jorge ; García Ortega, Lucía ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007RNase T1 is the best known representative of a large family of ribonucleolytic proteins secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among them by their cytotoxic character. They exert their toxic action by[...]texto impreso
Herrero Galán, Elías ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Gavilanes, José G. | Caister Academic Press | 2009Ribotoxins are a family of fungal extracellular ribonucleases which inactivate ribosomes by specifically cleaving a single phosphodiester bond located at the universally conserved sarcin/ricin loop of the large rRNA. The subsequent inhibition of[...]texto impreso
Álvarez García, Elisa ; Diago Navarro, Elizabeth ; Herrero Galán, Elías ; García Ortega, Lucía ; López Villarejo, Juan ; Olmo López, Nieves ; Díaz Orejas, Ramón ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2011Fungal ribotoxins are toxic secreted ribonucleases that cleave a conserved single phosphodiester bond located at the sarcin/ricin loop of the larger rRNA. This cleavage inactivates ribosomes leading to protein biosynthesis inhibition and cell de[...]texto impreso
Carreras Sangrà, Nelson ; Álvarez García, Elisa ; Herrero Galán, Elías ; Tomé, Jaime ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Bentham Science Publishers Ltd. | 2008Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin–ricin loop. This cleavage of a single phosphodiester bond inactiv[...]
