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Título:
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A novel visible light responsive nanosystem for cancer treatment
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Autores:
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Martínez Carmona, Marina ;
Lozano Borregón, Daniel ;
Baeza, Alejandro ;
Colilla, Montserrat ;
Vallet Regí, María
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Tipo de documento:
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texto impreso
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Editorial:
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Royal Society of Chemistry, 2017-09-19
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias: Química: Materiales
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Materia = Ciencias: Química: Química inorgánica
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Tipo = Artículo
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Resumen:
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A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyrin-caps grafted via reactive oxygen species (ROS)-cleavable linkages. In presence of Vis light the porphyrinnanocaps produce singlet oxygen molecules that break the sensitive-linker, which triggers pore uncapping and therefore allows the release of the entrapped cargo (topotecan, TOP). This new system takes advantage of thE non-toxicity and greater penetration capacity of Vis radiation and a double antitumor effect due to the drug release and the ROS production. In vitro tests with HOS osteosarcoma cancer cells reveal that TOP is able to be released in a controlled fashion inside the tumor cells. This research work constitutes a proof of concept that opens up promising expectations in the seeking for new alternatives for the treatment of cancer.
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En línea:
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https://eprints.ucm.es/id/eprint/45134/1/Nanoscale.pdf
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