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Título:
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Mesoporous Silica Nanoparticles Engineered for Ultrasound-Induced Uptake by Cancer Cells
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Autores:
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Paris, J.L. ;
Manzano García, Miguel ;
Cabañas Criado, Maria Victoria ;
Vallet Regí, María
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Tipo de documento:
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texto impreso
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Editorial:
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Royal Society of Chemistry, 2018-02-27
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias: Química: Materiales
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Materia = Ciencias Biomédicas: Farmacia: Química inorgánica
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Tipo = Artículo
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Resumen:
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A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is here presented. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. Initially, the anticancer-loaded nanocarriers are shielded with a polyethylene glycol layer. Upon exposure to high frequency ultrasound, the polymer shell detaches from the nanoparticles, exposing a positively-charged surface. That favors the internalization in human osteosarcoma cells, where release of topotecan takes place, drastically enhancing the cytotoxic effect.
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En línea:
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https://eprints.ucm.es/id/eprint/46645/1/Nanoscale_MVR_R1.pdf
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