|
Título:
|
MEG Delta Mapping Along the Healthy Aging-Alzheimer's Disease Continuum: Diagnostic Implications
|
|
Autores:
|
Fernández, Alberto ;
Turrero, Agustín ;
Zuluaga Arias, Pilar ;
Gil Gregorio, Pedro ;
Pozo, Francisco del ;
Maestú, Fernando ;
Moratti, Stephan
|
|
Tipo de documento:
|
texto impreso
|
|
Editorial:
|
IOS Press, 2013
|
|
Palabras clave:
|
Estado = Publicado
,
Materia = Ciencias: Matemáticas: Estadística aplicada
,
Materia = Ciencias Biomédicas: Medicina: Neurociencias
,
Materia = Ciencias Biomédicas: Biología
,
Tipo = Artículo
|
|
Resumen:
|
New diagnostic criteria for Alzheimer's disease (AD) stress the role of in vivo biomarkers. Neurophysiological markers are usually not considered as such criteria, although theoretical and practical reasons would justify them. In order to assess the value of neurophysiology as an AD biomarker, whole-head magnetoencephalographic (MEG) resting state recordings were obtained from 35 AD patients, 23 mild cognitive impairment (MCI) patients, and 24 healthy controls. The AD group was further split into two groups differing in severity according to the GDS/FAST criteria. A Minimum Norm Estimation procedure was utilized to estimate the cortical origin of slow brain oscillatory activity in the delta band (2–4 Hz). Eight regions of interest (ROIs) discriminated between AD patients and controls. Delta current density (DCD) in all ROIs showed a significant negative correlation with cognitive status (p
|
