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Gil, Anabel ; Rodríguez Escudero, Isabel ; Stumpf, Miriam ; Molina Martín, María ; Jiménez Cid, Víctor ; Pulido, Rafael | 2015-04-15Spatial regulation of the tumor suppressor PTEN is exerted through alternative plasma membrane, cytoplasmic, and nuclear subcellular locations. The N-terminal region of PTEN is important for the control of PTEN subcellular localization and funct[...]texto impreso
Mingo, Janire ; Rodríguez Escudero, Isabel ; Luna, Sandra ; Fernández Acero, Teresa ; Amo, Laura ; Jonasson, Amy R ; Zori, Roberto T ; López, José I ; Molina, María ; Cid, Víctor J. ; Pulido, Rafael | Springer Nature | 2018-04-30The PTEN gene encodes a master regulator protein that exerts essential functions both in the cytoplasm and in the nucleus. PTEN is mutated in the germline of both patients with heterogeneous tumor syndromic diseases, categorized as PTEN hamartom[...]texto impreso
Pulido, Rafael ; Baker, Suzanne J. ; Barata, Joao T. ; Carracedo, Arkaitz ; Cid, Víctor J. ; Chin-Sang, Ian D. ; Davé, Vrushank ; Hertog, Jeroen den ; Devreotes, Peter ; Eickholt, Britta J. ; Eng, Charis ; Furnari, Frank B. ; Georgescu, María Magdalena ; Gericke, Arne ; Hopkins, Benjamin ; Jiang, Xeujun ; Lee, Seung Rock ; Lösche, Mathias ; Malaney, Prerna ; Matias Guiu, Xavier ; Molina, María ; Pandolfi, Pier Paolo ; Parsons, Ramon ; Pinton, Paolo ; Rivas, Carmen ; Rocha, Rafael M. ; Rodríguez, Manuel S. ; Ross, Alonzo H. ; Serrano, Manuel ; Stambolic, Vuk ; Stiles, Bangyan ; Suzuki, Akira ; Tan, Seong Seng ; Tonks, Nicholas K. ; Trotman, Lloyd C. ; Wolff, Nicolas ; Woscholski, Rudiger ; Wu, Hong ; Leslie, Nicholas R. | American Association for the Advancement of Science | 2014-07-01The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTE[...]texto impreso
Rodríguez Escudero, Isabel ; Fernández Acero, Teresa ; Bravo, Ignacio ; Leslie, Nicholas R. ; Pulido, Rafael ; Molina, María ; Cid, Víctor J. | Elsevier | 2015-05-01The PTEN phosphoinositide 3-phosphatase is a tumor suppressor commonly targeted by pathologic missense mutations. Subject to multiple complex layers of regulation, its capital role in cancer relies on its counteracting function of class I phosph[...]
