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Gil Bona, Ana ; Parra Giraldo, Claudia Marcela ; Hernaez, Maria Luisa ; Reales Calderón, José Antonio ; Solis, Norma V. ; Filler, Scott G. ; Monteoliva Díaz, Lucía ; Gil, Concha | Elsevier | 2015-09-08The ability to switch from yeast to hyphal growth is essential for virulence in Candida albicans. The cell surface is the initial point of contact between the fungus and the host. In this work, a free-gel proteomic strategy based on tryptic dige[...]texto impreso
Reales Calderón, José Antonio ; Sylvester, Marc ; Strijbis, Karin ; Jensen, Ole N. ; Nombela, César ; Molero, Gloria ; Gil, Concha | Elsevier | 2013-07-05Macrophages play a pivotal role in the prevention of Candida albicans infections. Yeast recognition and phagocytosis by macrophages is mediated by Pattern Recognition Receptors (PRRs) that initiate downstream signal transduction cascades by prot[...]texto impreso
Reales Calderón, José Antonio ; Vaz, Catarina ; Monteoliva Díaz, Lucía ; Molero, Gloria ; Gil, Concha | American Chemical Society | 2016-10-14The effectiveness of macrophages in the response to systemic candidiasis is crucial to an effective clearance of the pathogen. The secretion of proteins, mRNAs, non-coding RNAs and lipids through extracellular vesicles (EVs) is one of the mechan[...]texto impreso
Vaz, Catarina Oliveira ; Reales Calderón, José Antonio ; Pitarch, Aida ; Vellosillo, Perceval ; Trevisan Herraz, Marco ; Hernáez Sánchez, Maria Luisa ; Monteoliva Díaz, Lucía ; Gil García, Concha | ACS | 2019-04-15Macrophages are involved in the primary human response to Candida albicans. After pathogen recognition, signaling pathways are activated, leading to the production of cytokines, chemokines, and antimicrobial peptides. ATP binding proteins are cr[...]texto impreso
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Reales Calderón, José Antonio ; Aguilera Montilla, Noemí ; Corbí, Ángel L. ; Molero, Gloria ; Gil, Concha | Wiley | 2014-06In response to different stimuli, macrophages can differentiate into either a pro-inflammatory subtype (M1, classically activated macrophages) or acquire an anti-inflammatory phenotype (M2, alternatively activated macrophages). Candida albicans [...]texto impreso
Reales Calderón, José Antonio ; Martínez Solano, Laura ; Martinez Gomariz, Montserrat ; Nombela, César ; Molero, Gloria ; Gil, Concha | Elsevier | 2012-08In previous proteomic studies on the response of murine macrophages against Candida albicans, many differentially expressed proteins involved in processes like inflammation, cytoskeletal rearrangement, stress response and metabolism were identif[...]texto impreso
Corona, Fernando ; Reales Calderón, José Antonio ; Gil, Concha ; Martínez, José Luis | Nature Research | 2018-11-14Bacterial physiology is regulated at different levels, from mRNA synthesis to translational regulation and protein modification. Herein, we propose a parameter, dubbed post-transcriptional variation (PTV), that allows extracting information on p[...]
