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Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina ; Carrión Caballo, Mar ; Pérez García, Selene ; Villanueva Romero, Raúl ; González Álvaro, Isidoro ; Gutiérrez Cañas, Irene ; Lamana, Amalia ; Martínez, Carmen | Frontiers Media | 2019-10-22The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins. VPAC receptors seem to preferentially interact with Gs in [...]texto impreso
Martínez, Carmen ; Juarranz Moratilla, Yasmina ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Villanueva Romero, Raúl ; Castro Moreno, David ; Lamana, Amalia ; Mellado, Mario ; González Álvaro, Isidoro ; Gomáriz, Rosa P. | MDPI | 2019-12-20The neuroendocrine and immune systems are coordinated to maintain the homeostasis of the organism, generating bidirectional communication through shared mediators and receptors. Vasoactive intestinal peptide (VIP) is the paradigm of an endogenou[...]texto impreso
Lamana, Amalia ; Villares, Ricardo ; Seoane Valiño, Iria V. ; Andrés, Nuria ; Lucas, Pilar ; Emery, Paul ; Vital, Edward M. ; Triguero-Martínez, Ana ; Márquez, Ana ; Ortiz, Ana M. ; Maxime, Robin ; Martínez, Carmen ; Martín, Javier ; Gomáriz, Rosa P. ; Ponchel, Frederique ; González-Álvaro, Isidoro ; Mellado, Mario | Frontiers Media | 2020-06-26Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by an autoimmune response in the joints and an exacerbation of cytokine responses. A minority of patients with RA experience spontaneous remission, but most will show mode[...]texto impreso
Seoane Valiño, Iria V. ; Martínez, Carmen ; Garcia-Vicuña, Rosario ; Ortiz, Ana M. ; Juarranz Moratilla, Yasmina ; Talayero, Vanessa C. ; González-Álvaro, Isidoro ; Gomáriz, Rosa P. ; Lamana, Amalia | Nature Publishing Group | 2018-02-01We previously reported that early arthritis (EA) patients with low vasoactive intestinal peptide (VIP) serum levels demonstrate a worse clinical disease course. In this study, we analysed whether variants in the VIP gene correlated with its seru[...]texto impreso
Valiño Seoane, Iria ; Tomero, Eva ; Martínez, Carmen ; Garcia-Vicuña, Rosario ; Juarranz Moratilla, Yasmina ; Lamana, Amalia ; Ocón, Elena ; Ortiz, Ana M. ; Gómez-León, Nieves ; González-Álvaro, Isidoro ; Pérez-Gomáriz, Rosa | Springer | 2015-02Spondyloarthritis (SpA) is a family of inflammatory diseases sharing clinical, genetic, and radiological features. While crucial for tailoring early interventions, validated prognostic biomarkers are scarce in SpA. We analyze the correlation bet[...]
