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Jimeno, Rebeca ; Leceta Martínez, Javier ; Garín, Marina ; Ortiz, Ana M. ; Mellado, Mario ; Rodríguez Frade, José Miguel ; Martínez, Carmen ; Pérez García, Selene ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | The Society for Leukocyte Biology. | 2015-08Several studies in humans indicate the implication of Th17 cells in RA. Therapies targeting their pathogenicity, as well as their plasticity to the Th17/1 phenotype, could ameliorate the progression of the pathology. The neuroendocrine environme[...]texto impreso
Jimeno Lumeras, Rebeca Gema ; Pérez Gomáriz, Rosa Mª ; Garín, Marina ; Gutiérrez Cañas, Irene ; González Álvaro, Isidoro ; Carrión Caballo, Mar ; Galindo, María ; Leceta Martínez, Javier ; Juarranz Moratilla, Yasmina | Springer | 2015Our aim is to study the behavior of memory Th cells (Th17, Th17/1, and Th1 profiles) from early rheumatoid arthritis (eRA) patients after their in vitro activation/expansion to provide information about its contribution to RA chronicity. Moreove[...]texto impreso
Jimeno Lumeras, Rebeca Gema ; Leceta Martínez, Javier ; Martínez, Carmen ; Gutiérrez-Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Garín, Marina ; Mellado, Mario ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | Springer | 2014-11The cytokine microenvironment modulates CD4 T cell differentiation causing the shift of naïve CD4 T cells into different cell subsets. This process is also regulated by modulators such as VIP, a neuropeptide with known immunomodulatory propertie[...]
