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Reales Calderón, José Antonio ; Sylvester, Marc ; Strijbis, Karin ; Jensen, Ole N. ; Nombela, César ; Molero, Gloria ; Gil, Concha | Elsevier | 2013-07-05Macrophages play a pivotal role in the prevention of Candida albicans infections. Yeast recognition and phagocytosis by macrophages is mediated by Pattern Recognition Receptors (PRRs) that initiate downstream signal transduction cascades by prot[...]texto impreso
Reales Calderón, José Antonio ; Vaz, Catarina ; Monteoliva Díaz, Lucía ; Molero, Gloria ; Gil, Concha | American Chemical Society | 2016-10-14The effectiveness of macrophages in the response to systemic candidiasis is crucial to an effective clearance of the pathogen. The secretion of proteins, mRNAs, non-coding RNAs and lipids through extracellular vesicles (EVs) is one of the mechan[...]texto impreso
Moreno Rodríguez, Ana Cristina ; Torrado Durán, Susana ; Molero, Gloria ; García Rodríguez, Juan José ; Torrado-Santiago, Santiago | Elsevier | 2015-08-06The aim of this work is to study the micelle systems of amphotericin B (AmB) and surfactant sodium deoxycholate (NaDC) as possible formulations to treat brain fungal infections. Fungizone(®) and Ambisome(®) were used as AmB references. The parti[...]texto impreso
Ruiz, Helga K. ; Serrano, Dolores R. ; Dea Ayuela, María Auxiliadora ; Bilbao Ramos, Pablo Estanislao ; Bolás Fernández, Francisco ; Torrado, Juan J. ; Molero, Gloria | Elsevier | 2014-07-03Amphotericin B (AmB) has a broad antifungal and leishmanicidal activity with low incidence of clinical resistance. Its parenteral administration has high risk of nephrotoxicity that limits its use. In order to treat cutaneous infections, AmB top[...]texto impreso
Reales Calderón, José Antonio ; Aguilera Montilla, Noemí ; Corbí, Ángel L. ; Molero, Gloria ; Gil, Concha | Wiley | 2014-06In response to different stimuli, macrophages can differentiate into either a pro-inflammatory subtype (M1, classically activated macrophages) or acquire an anti-inflammatory phenotype (M2, alternatively activated macrophages). Candida albicans [...]texto impreso
Reales Calderón, José Antonio ; Martínez Solano, Laura ; Martinez Gomariz, Montserrat ; Nombela, César ; Molero, Gloria ; Gil, Concha | Elsevier | 2012-08In previous proteomic studies on the response of murine macrophages against Candida albicans, many differentially expressed proteins involved in processes like inflammation, cytoskeletal rearrangement, stress response and metabolism were identif[...]
