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Hernández Torres, Gloria ; Enríquez Palacios, Ernesto ; Mecha Rodríguez, Miriam ; Feliú Martínez, Ana ; Rueda Zubiaurre, Ainoa ; Angelina Querencias, Alba ; Martín Cruz, Leticia ; Martín Fontecha, María del Mar ; Palomares, Oscar ; Guaza Rodríguez, Carmen ; Peña Cabrera, Eduardo ; López Rodríguez, María L. ; Ortega Gutiérrez, Silvia | American Chemical Society (ACS) | 2018-05-07Serotonin (5-HT) modulates key aspects of the immune system. However, its precise function and the receptors involved in the observed effects have remained elusive. Among the different serotonin receptors, 5-HT1A plays an important role in the i[...]texto impreso
Marín Ramos, Nagore Isasbel ; Piñar Pinedo, María del Carmen ; Vázquez Villa, Henar ; Martín Fontecha, María del Mar ; Gonzalez Wong, Ángel ; Canales Mayordomo, Ángeles ; Algar Lizana, Sergio ; Mayo Mariscal de Gante, Paloma P. ; Jiménez-Barbero, Jesús ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Pardo Carrasco, Leonardo ; Ortega Gutiérrez, Silvia ; Viso Beronda, Alma ; López Rodríguez, María Luz | Wiley | 2017-01-31Despite more than three decades of intense effort, no anti-Ras therapies have reached clinical application. Contributing to this failure has been an underestimation of Ras complexity and a dearth of structural information. In this regard, recent[...]texto impreso
Martín Fontecha, María del Mar ; Angelina Querencias, Alba ; Rückert, Beate ; Rueda Zubiaurre, Ainoa ; Martín Cruz, Leticia ; Veen, Willem van de ; Akdis, Mübeccel ; Ortega Gutiérrez, Silvia ; López Rodríguez, María Luz ; Akdis, Cezmi A. ; Palomares, Oscar | American Chemical Society (ACS) | 2018-02-21The human endogenous cannabinoid system (ECS) regulates key physiological processes and alterations in its signaling pathways, and endocannabinoid levels are associated with diseases such as neurological and neuropsychiatric conditions, cancer, [...]texto impreso
Palomares Gracia, Oscar ; Akdis, Mübeccel ; Martín Fontecha, María del Mar ; Akdis, Cezmi A. | John Wiley & Sons | 2017-07Allergy is a major public health problem with a high socio-economic impact. The number of allergic patients is expected to reach to four billion within two decades when the World's population reaches to 10 billion. Our knowledge on the molecular[...]texto impreso
González Vera, Juan Antonio ; Medina Muñoz, Rocío Almudena ; Martín Fontecha, María del Mar ; Gonzalez Wong, Ángel ; Fuente Mendizábal, Tania de la ; Vázquez Villa, Henar ; García Cárceles, Javier ; Botta, Joaquín ; McCormick, Peter J. ; Benhamú Salama, Bellinda ; Pardo Carrasco, Leonardo ; López Rodríguez, María Luz | Nature Publishing Group | 2017Serotonin 5-HT 6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these molecules as a drug class for the treatment of Alzheimer's diseas[...]texto impreso
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Artola Pérez de Azanza, Marta Elena ; Ruiz Ávila, Laura, Laura B. ; Ramírez Aportela, Erney ; Fernando Martínez, R. ; Araujo Bazán, Lidia ; Vázquez Villa, Henar ; Martín Fontecha, María del Mar ; Oliva Blanco, María Ángela ; Martín Galiano, Antonio Javier ; Chacón Montes, Pablo ; López Rodríguez, María Luz ; Andreu Rodríguez, José Manuel ; Huecas Gayo, Sonia | RSC | 2017FtsZ is a widely conserved tubulin-like GTPase that directs bacterial cell division and a new target for antibiotic discovery. This protein assembly machine cooperatively polymerizes forming single-stranded filaments, by means of self-switching [...]texto impreso
Camicia, Federico ; Celentano, Ana M. ; Johns, Malcolm E. ; Chan, John D. ; Maldonado, Lucas ; Vaca, Hugo ; Siervi, Nicolás Di ; Kamenetzky, Laura ; Gamo Albero, Ana María ; Ortega Gutiérrez, Silvia ; Martín Fontecha, María del Mar ; Davio, Carlos ; Marchant, Jonathan S. ; Rosenzvit, Mara C. | Public Library Science | 2018-02-09Background: Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional properties of G protein coupled receptors (GPCRs) which have proved to be highly druggable [...]
