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Título:
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Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging
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Autores:
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Santos, Harrison D. A. ;
Zabala Gutiérrez, Irene ;
Shen, Yingli ;
Lifante, José ;
Ximendes, Erving ;
Laurenti, Marco ;
Méndez González, Diego ;
Melle Hernández, Sonia ;
Gómez Calderón, Óscar ;
Lopez Cabarcos, Enrique ;
Fernández Monsalve, Nuria ;
Chavez Coria, Irene ;
Lucena Agell, Daniel ;
Monge, Luis ;
Mackenzie, Mark D. ;
Marqués Hueso, José ;
Jones, Callum M. S. ;
Jacinto, Carlos ;
Rosal, Blanca, del ;
Kar, Ajoy K. ;
Rubio Retama, Jorge ;
Jaque García, Daniel
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Tipo de documento:
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texto impreso
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Editorial:
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Nature Publishing Group, 2020-06-10
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Óptica y optometría: Óptica geométrica e instrumental
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Materia = Ciencias Biomédicas: Óptica y optometría: Técnicas de la imagen
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Tipo = Artículo
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Resumen:
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Optical probes operating in the second near-infrared window (NIR-II, 1,000-1,700?nm), where tissues are highly transparent, have expanded the applicability of fluorescence in the biomedical field. NIR-II fluorescence enables deep-tissue imaging with micrometric resolution in animal models, but is limited by the low brightness of NIR-II probes, which prevents imaging at low excitation intensities and fluorophore concentrations. Here, we present a new generation of probes (Ag2S superdots) derived from chemically synthesized Ag2S dots, on which a protective shell is grown by femtosecond laser irradiation. This shell reduces the structural defects, causing an 80-fold enhancement of the quantum yield. PEGylated Ag2S superdots enable deep-tissue in vivo imaging at low excitation intensities (
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En línea:
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https://eprints.ucm.es/id/eprint/60947/1/Sonia%20Melle_2020_s41467-020-16333-2.pdf
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