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Marín Ramos, Nagore Isasbel ; Piñar Pinedo, María del Carmen ; Vázquez Villa, Henar ; Martín Fontecha, María del Mar ; Gonzalez Wong, Ángel ; Canales Mayordomo, Ángeles ; Algar Lizana, Sergio ; Mayo Mariscal de Gante, Paloma P. ; Jiménez-Barbero, Jesús ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Pardo Carrasco, Leonardo ; Ortega Gutiérrez, Silvia ; Viso Beronda, Alma ; López Rodríguez, María Luz | Wiley | 2017-01-31Despite more than three decades of intense effort, no anti-Ras therapies have reached clinical application. Contributing to this failure has been an underestimation of Ras complexity and a dearth of structural information. In this regard, recent[...]texto impreso
González Vera, Juan Antonio ; Medina Muñoz, Rocío Almudena ; Martín Fontecha, María del Mar ; Gonzalez Wong, Ángel ; Fuente Mendizábal, Tania de la ; Vázquez Villa, Henar ; García Cárceles, Javier ; Botta, Joaquín ; McCormick, Peter J. ; Benhamú Salama, Bellinda ; Pardo Carrasco, Leonardo ; López Rodríguez, María Luz | Nature Publishing Group | 2017Serotonin 5-HT 6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these molecules as a drug class for the treatment of Alzheimer's diseas[...]texto impreso
González Gil, Inés ; Zian, Debora ; Vázquez Villa, Henar ; Ortega Gutiérrez, Silvia ; López Rodríguez, María L. | Royal Society of Chemistry (UK) | 2015Lysophospholipids are lipid molecules that are receiving growing attention because, in addition to their structural function in the cell membrane, they are now regarded as important regulators for diverse biological functions through activation [...]texto impreso
Artola Pérez de Azanza, Marta Elena ; Ruiz Ávila, Laura, Laura B. ; Ramírez Aportela, Erney ; Fernando Martínez, R. ; Araujo Bazán, Lidia ; Vázquez Villa, Henar ; Martín Fontecha, María del Mar ; Oliva Blanco, María Ángela ; Martín Galiano, Antonio Javier ; Chacón Montes, Pablo ; López Rodríguez, María Luz ; Andreu Rodríguez, José Manuel ; Huecas Gayo, Sonia | RSC | 2017FtsZ is a widely conserved tubulin-like GTPase that directs bacterial cell division and a new target for antibiotic discovery. This protein assembly machine cooperatively polymerizes forming single-stranded filaments, by means of self-switching [...]
