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Marín Ramos, Nagore Isasbel ; Piñar Pinedo, María del Carmen ; Vázquez Villa, Henar ; Martín Fontecha, María del Mar ; Gonzalez Wong, Ángel ; Canales Mayordomo, Ángeles ; Algar Lizana, Sergio ; Mayo Mariscal de Gante, Paloma P. ; Jiménez-Barbero, Jesús ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Pardo Carrasco, Leonardo ; Ortega Gutiérrez, Silvia ; Viso Beronda, Alma ; López Rodríguez, María Luz | Wiley | 2017-01-31Despite more than three decades of intense effort, no anti-Ras therapies have reached clinical application. Contributing to this failure has been an underestimation of Ras complexity and a dearth of structural information. In this regard, recent[...]texto impreso
Martín Fontecha, María del Mar ; Angelina Querencias, Alba ; Rückert, Beate ; Rueda Zubiaurre, Ainoa ; Martín Cruz, Leticia ; Veen, Willem van de ; Akdis, Mübeccel ; Ortega Gutiérrez, Silvia ; López Rodríguez, María Luz ; Akdis, Cezmi A. ; Palomares, Oscar | American Chemical Society (ACS) | 2018-02-21The human endogenous cannabinoid system (ECS) regulates key physiological processes and alterations in its signaling pathways, and endocannabinoid levels are associated with diseases such as neurological and neuropsychiatric conditions, cancer, [...]texto impreso
Gil Ordóñez, Ana ; Martín Fontecha, Mar ; Ortega Guitérrez, Silvia ; López Rodríguez, María Luz | Elsevier | 2018-11Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2-AG). Besides this role, MAGL has progressively acquired a growing imp[...]texto impreso
González Vera, Juan Antonio ; Medina Muñoz, Rocío Almudena ; Martín Fontecha, María del Mar ; Gonzalez Wong, Ángel ; Fuente Mendizábal, Tania de la ; Vázquez Villa, Henar ; García Cárceles, Javier ; Botta, Joaquín ; McCormick, Peter J. ; Benhamú Salama, Bellinda ; Pardo Carrasco, Leonardo ; López Rodríguez, María Luz | Nature Publishing Group | 2017Serotonin 5-HT 6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these molecules as a drug class for the treatment of Alzheimer's diseas[...]texto impreso
Marín Ramos, Nagore Isasbel ; Balabasquer Peña, Moisés ; Ortega Nogales, Francisco Jesús ; Torrecillas, Iván R. ; Gil Ordóñez, Ana ; Marcos Ramiro, Beatriz ; Aguilar Garrido, Pedro ; Cushman, Ian ; Romero, Antonio ; Medrano, Francisco J. ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Philips, Mark R. ; Campillo, Mercedes ; Gallardo Delgado, Miguel ; Martín Fontecha, Mar ; López Rodríguez, María Luz ; Ortega Gutiérrez, Silvia | American Chemical Society (ACS) | 2019-06-10Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the [...]texto impreso
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Artola Pérez de Azanza, Marta Elena ; Ruiz Ávila, Laura, Laura B. ; Ramírez Aportela, Erney ; Fernando Martínez, R. ; Araujo Bazán, Lidia ; Vázquez Villa, Henar ; Martín Fontecha, María del Mar ; Oliva Blanco, María Ángela ; Martín Galiano, Antonio Javier ; Chacón Montes, Pablo ; López Rodríguez, María Luz ; Andreu Rodríguez, José Manuel ; Huecas Gayo, Sonia | RSC | 2017FtsZ is a widely conserved tubulin-like GTPase that directs bacterial cell division and a new target for antibiotic discovery. This protein assembly machine cooperatively polymerizes forming single-stranded filaments, by means of self-switching [...]
