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Título:
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Interactions between high and low-virulence isolates of Neospora Caninum and the bovine placenta
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Autores:
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Jiménez Pelayo, Laura
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Tipo de documento:
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texto impreso
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Editorial:
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Universidad Complutense de Madrid, 2019-11-29
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = No publicado
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Materia = Ciencias Biomédicas: Veterinaria: Parasitología
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Tipo = Tesis
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Resumen:
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Bovine neosporosis is one of the most important causes of abortion in cattle worldwide and Neospora caninum, an apicomplexan protozoan parasite, is the causal agent of the disease. Millionaire economic losses have been estimated in infected cattle, mainly associated with the reproductive failure. N. caninum is very effective at crossing the placental barrier and placental damage is crucial in the pathogenesis of abortion. In addition, infection during pregnancy poses a challenge for the immune system of pregnant cows. Changes in the T helper 1 and T helper 2 balance in the placenta during gestation have been associated with abortion. Bovine trophoblast and caruncular cell layers are key cellular components at the maternal-foetal interface in placentomes, playing a fundamental role in placental functionality. In addition to their role as a barrier, those cells are able to recognize and induce immune responses against N. caninum, participating in the initiation of innate immune responses at the placental level as well as in the development of an adaptative immune response...
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En línea:
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https://eprints.ucm.es/id/eprint/59935/1/T41915.pdf
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