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ADP-ribosyltransferases (ADPRTs) form an interesting class of enzymes with well-established roles as potent bacterial toxins and metabolic regulators. ADPRTs catalyze the transfer of the ADP-ribose moiety from NAD(+) onto specific substrates inc[...]texto impreso
Soumelis, Vassili ; Reche, Pedro A ; Kanzler, Holger ; Yuan, Wei ; Edward, Gina ; Homey, Bernhart ; Gilliet, Michel ; Ho, Steve ; Antonenko, Svetlana ; Lauerma, Annti ; Smith, Kathleen ; Gorman, Daniel ; Zurawski, Sandra M. ; Abrams, Jon ; Menon, Satish ; McClanahan, Terri ; Waal-Malefyt, Rene de ; Bazan, Fernando ; Kastelein, Robert A. ; Liu, Yong-Jun | Nature Publishing Group | 2002Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells [...]texto impreso
Reche, Pedro A ; Soumelis, Vassili ; Gorman, D M ; Clifford, T ; Liu, MR ; Travis, M ; Zurawski, Sandra M. ; Johnston, J ; Liu, Yong-Jun ; Spits, H ; Waal-Malefyt, Rene de ; Kastelein, Robert A. ; Bazan, Fernando | The American Association of Immunologists | 2001The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal [...]texto impreso
Otto, Helge ; Reche, Pedro A ; Bazan, Fernando ; Dittmar, Katharina ; Haag, Friedrich ; Koch-Nolte, Friedrich | 2005BACKGROUND: ADP-ribosylation is an enzyme-catalyzed posttranslational protein modification in which mono(ADP-ribosyl)transferases (mARTs) and poly(ADP-ribosyl)transferases (pARTs) transfer the ADP-ribose moiety from NAD onto specific amino acid [...]texto impreso
Glowacki, Gustavo ; Braren, Rickmer ; Firner, Kathrin ; Nissen, Marion ; Kühl, Maren ; Reche, Pedro A ; Bazan, Fernando ; Cetkovic-Cvrlje, Marina ; Leiter, Edward ; Haag, Friedrich ; Koch-Nolte, Friedrich | 2002ADP-ribosyltransferases including toxins secreted by Vibrio cholera, Pseudomonas aerurginosa, and other pathogenic bacteria inactivate the function of human target proteins by attaching ADP-ribose onto a critical amino acid residue. Cross-specie[...]
