| Título: | Elevated intraocular pressure increases melatonin levels in the aqueous humour |
| Autores: | Alkozi, Hanan Awad ; Sánchez Naves, Juan ; Pérez de Lara, María Jesús ; Carracedo Rodríguez, Juan Gonzalo ; Fonseca, Begoña ; Martínez Águila, Alejandro ; Pintor, Jesús |
| Tipo de documento: | texto impreso |
| Editorial: | John Wiley & Sons Ltd., 2016-09-06 |
| Dimensiones: | application/pdf |
| Nota general: | info:eu-repo/semantics/restrictedAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias Biomédicas: Medicina: Oftalmología , Materia = Ciencias Biomédicas: Óptica y optometría: Óptica fisiológica , Tipo = Artículo |
| Resumen: |
Purpose: To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma. Methods : A total of 37 eyes of 37 patients who underwent cataract surgery were included in the study and were divided into normotensive patients, with IOP below 21 mmHg (n = 23), and hypertensive patients, with IOP > 21 mmHg (n = 14). Glaucomatous DBA/2J (n = 6) and control C57BL/6J (n = 6) mice presenting 3 and 12 months of age for each strain were also used. Human and mice aqueous humours were aspirated using a 30-gauge Rycroft cannula on a tuberculin syringe and further processed to quantify melatonin by high-performance liquid chromatography analysis. Results: Melatonin levels in normotensive patients (IOP below 21 mmHg) presented values as medians (first quartile; third quartile) of 14.62 (5.38;37.99) ng/ml (n = 23), while hypertensive patients (IOP above 21 mmHg) showed melatonin concentrations of 46.63 (10.28; 167.28) ng/ml (n = 14; p Conclusion: Patients with high IOP present increased concentrations of melatonin in their aqueous humour compared to normotensive patients. This has been confirmed in a glaucomatous animal model in which it has been possible to see a correlation between the development of the pathology, with an increase in IOP, and a concomitant elevation of melatonin in the aqueous humour. |
| En línea: | https://eprints.ucm.es/41664/1/Alkozi_et_al-2016-Acta_Ophthalmologica.pdf |
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