| Título: | Short-term Effect of Scleral Lens on the Dry Eye Biomarkers in Keratoconus |
| Autores: | Carracedo Rodríguez, Juan Gonzalo ; Serramito Blanco, María ; Martín Gil, Alba ; Wang, Zicheng ; Carballo Álvarez, Jesús ; Pintor, Jesús |
| Tipo de documento: | texto impreso |
| Editorial: | Lippincott Williams & Wilkins, 2016-02 |
| Dimensiones: | application/pdf |
| Nota general: | info:eu-repo/semantics/restrictedAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias Biomédicas: Medicina: Oftalmología , Materia = Ciencias Biomédicas: Óptica y optometría: Lentes de contacto , Materia = Ciencias Biomédicas: Óptica y optometría: Óptica oftálmica , Tipo = Artículo |
| Resumen: |
Purpose: To evaluate the most important signs of dry eye, such as osmolarity, inflammation, and diadenosine tetraphosphate (Ap4A) concentration before and after wearing scleral lenses for 8 h in keratoconus patients. Methods: A pilot, experimental, short-term study involved 26 keratoconus patients (average age, 36.95 ± 8.95 years). They voluntarily enrolled in the study at the Optometry Clinic of the Faculty of Optics and Optometry in the University Complutense of Madrid. They were divided into two groups: patients with intrastromal corneal ring, the ICRS group, and patients without ICRS, the keratoconus (KC) group. Ocular Surface Disease Index questionnaire, the Schirmer test without anesthesia, tear break-up time, matrix metalloproteinase 9 (MMP-9) concentration, osmolarity, and Ap4A concentration were evaluated before and after wearing a scleral lens for 8 h. Results: The patients wore the scleral lenses from 6 to 9 h, with a mean of 7.59 ± 0.73 h. The mean scleral lens sag for all patients was 4310 ± 166.31 ?m, ranging from 4200 ?m to 4800 ?m. No significant changes in the Schirmer test and tear break-up time were found for either group. Ocular Surface Disease Index scores were statistically lower after wearing scleral lenses for both groups (p 0.05). Conclusions: Short-term scleral lens wearing improves the symptomatology and some signs of dry eye, such as osmolarity and Ap4A concentration. The increase of MMP-9 concentration could be caused by tear film stagnation and use of preserved saline. |
| En línea: | https://eprints.ucm.es/42130/1/Short%20term%20effect_OptVisScien-2015.pdf |
Ejemplares
| Estado |
|---|
| ningún ejemplar |
