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Título:
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Dipole density of low-frequency and spike magnetic activity: A reliable procedure in presurgical evaluation of temporal lobe epilepsy
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Autores:
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Fernández, Alberto ;
de Sola, Rafael G. ;
Amo, Carlos ;
Turrero, Agustín ;
Zuluaga Arias, Pilar ;
Maestú, Fernando ;
Campo, Pablo ;
Ortiz, Tomás
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Tipo de documento:
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texto impreso
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Editorial:
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American Clinical Neurophysiology Society, 2004-07
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias: Matemáticas: Estadística aplicada
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Materia = Ciencias Biomédicas: Biología
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Tipo = Artículo
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Resumen:
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Conventional visual analysis and dipole density analysis of magnetoencephalographic data for both spike and low-frequency magnetic activity were compared for presurgical evaluation in temporal lobe epilepsy (TLE) in a sample of 26 drug-resistant operated TLE patients. A series of logistic regression analyses were performed. Dipole density sensitivity was superior to visual localization analysis. Three separated logistic models were calculated for interictal spikes, low-frequency magnetic activity, and the combination of both measures. A combined interictal spike/low-frequency magnetic activity model predicted correctly the operated temporal lobe in all patients. Clear-cut criteria for the probability model are proposed that are valid for 92.3% of cases in the sample. The quantitative approach proposed by this study is an evidence-based model for presurgical evaluation of temporal lobe epilepsy, which improves previous magnetoencephalographic investigations and establishes working clinical criteria for patient evaluation in TLE.
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