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Gallego Collado, Beatriz Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salinas Navarro, Manuel Ángel ; Ortín Martínez, Arturo ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Biomed Central Ltd | 2012-05-12Background Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative disease characterized by an irreversible decrease in ganglion cells and their axons. Macroglial and microglial cells appear to play an important role in the [...]texto impreso
Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Gallego Collado, Beatriz Isabel ; García Martín, Elena Salobrar ; Valiente Soriano, Francisco Javier ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Elsevier | 2015Most studies employing experimental models of unilateral glaucoma have used the normotensive contralateral eye as the normal control. However, some studies have recently reported the activation of the retinal macroglia and microglia in the uninj[...]texto impreso
Rojas López, María Blanca ; Gallego Collado, Beatriz Isabel ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto | BioMed Central Ltd. | 2014-07-26Background: Glaucomatous optic neuropathy, a leading cause of blindness, can progress despite control of intraocular pressure - currently the main risk factor and target for treatment. Glaucoma progression shares mechanisms with neurodegenerativ[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; Hoz Montañana, Rosa de ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Rojas Lozano, Pilar ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | Elsevier | 2020Glaucoma is an age-related neurodegenerative disease that begins at the onset of aging. In this disease, there is an involvement of the immune system and therefore of the microglia. The purpose of this study is to evaluate the microglial activat[...]texto impreso
Pérez de Lara, María Jesús ; Avilés Trigueros, Marcelino ; Guzmán Aránguez, Ana Isabel ; Valiente Soriano, Francisco Javier ; Villa Polo, Pedro de la ; Vidal Sanz, Manuel ; Pintor, Jesús | Elsevier | 2019-05-16Glaucoma is a common cause of visual impairment and blindness, characterized by retinal ganglion cell (RGC) death. The mechanisms that trigger the development of glaucoma remain unknown and have gained significant relevance in the study of this [...]texto impreso
Fernández Arrabal, José A. ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Marco López, Eva María ; Martín Sánchez, Beatriz ; Flores Salguero, Elena ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Barrios Sabador, Vicente ; Avilés Trigueros, Marcelino ; Valiente Soriano, Francisco Javier ; Miralles de Imperial-Ollero, Juan A. ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel ; López Gallardo, Meritxell ; Ramírez Sebastián, Ana Isabel | MDPI | 2021-02-19Signaling mediated by cytokines and chemokines is involved in glaucoma-associated neuroinflammation and in the damage of retinal ganglion cells (RGCs). Using multiplexed immunoassay and immunohistochemical techniques in a glaucoma mouse model at[...]texto impreso
Hoz Montañana, María Rosa de ; Gallego Collado, Beatriz Isabel ; Ramírez Sebastián, Ana Isabel ; Rojas López, María Blanca ; Salazar Corral, Juan José ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2013-12-18In the mouse model of unilateral laser-induced ocular hypertension (OHT) the microglia in both the treated and the normotensive untreated contralateral eye have morphological signs of activation and up-regulation of MHC-II expression in comparis[...]
