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Título:
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p38? is essential for cell cycle progression and liver tumorigenesis
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Autores:
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Tomás-Loba, Antonia ;
Manieri, Elisa ;
González-Terán, Bárbara ;
Mora, Alfonso ;
Leiva-Vega, Luis ;
Santamans, Ayelén M. ;
Romero-Becerra, Rafael ;
Rodríguez, Elena ;
Pintor-Chocano, Aránzazu ;
Feixas, Ferran ;
López, Juan Antonio ;
Caballero, Beatriz ;
Trakala, Marianna ;
Blanco, Óscar ;
Torres, Jorge L. ;
Hernández-Cosido, Lourdes ;
Montalvo-Romeral, Valle ;
Matesanz, Nuria ;
Roche-Molina, Marta ;
Bernal, Juan Antonio ;
Mischo, Hannah ;
León, Marta ;
Caballero, Ainoa ;
Miranda-Saavedra, Diego ;
Ruiz-Cabello, Jesús ;
Nevzorova, Yulia A. ;
Cubero, Francisco Javier ;
Bravo, Jerónima ;
Vázquez, Jesús ;
Malumbres, Marcos ;
Marcos, Miguel ;
Osuna, Silvia ;
Sabio, Guadalupe
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Tipo de documento:
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texto impreso
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Editorial:
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Nature Research, 2019-04-10
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/restrictedAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Gastroenterología y hepatología
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Materia = Ciencias Biomédicas: Medicina: Oncología
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Materia = Ciencias Biomédicas: Biología: Genética
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Tipo = Artículo
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Resumen:
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The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)–cyclin protein complex1. However, control of the G0-to-G1 transition is not completely understood. Here we demonstrate that p38 MAPK gamma (p38?) acts as a CDK-like kinase and thus cooperates with CDKs, regulating entry into the cell cycle. p38? shares high sequence homology, inhibition sensitivity and substrate specificity with CDK family members. In mouse hepatocytes, p38? induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. Lack of p38? or treatment with the p38? inhibitor pirfenidone protects against the chemically induced formation of liver tumours. Furthermore, biopsies of human hepatocellular carcinoma show high expression of p38?, suggesting that p38? could be a therapeutic target in the treatment of this disease.
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En línea:
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https://eprints.ucm.es/id/eprint/57170/1/Ruiz-Cabello-Nevzorova-DGFM-p38%CE%B3-is-essential.pdf
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