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Herrero-Vanrell, Rocio ; Vicario de la Torre, Marta ; Andrés-Guerrero, Vanessa ; Barbosa-Alfaro, Deyanira ; Molina-Martínez, Irene Teresa ; Bravo-Osuna, Irene | Elsevier | 2013Ocular drug delivery is one of the most challenging fields of pharmaceutical research. They are generally employed to overcome the static (different layers of cornea, sclera, and retina including blood aqueous and blood-retinal barriers) and dyn[...]texto impreso
Bravo-Osuna, Irene ; Vicario-de-la-Torre, Marta ; Andrés-Guerrero, Vanessa ; Sánchez-Nieves, Javier ; Guzmán-Navarro, Manuel ; de la Matad, F. Javier ; Gómez, Rafael ; de las Heras, Beatriz ; Argüesoh, Pablo ; Poncheli, Gilles ; Herrero-Vanrell, Rocio ; Molina-Martínez, Irene Teresa | American Chemical Society (ACS) | 2016-09-06Purpose: To determine the potential use of water-soluble anionic and cationic carbosilane dendrimers (Generations 1-3) as mucoadhesive polymers in eyedrop formulations. Methods: Cationic carbosilane dendrimers decorated with ammonium –NH3 + gro[...]texto impreso
Bravo-Osuna, Irene ; Andrés-Guerrero, Vanessa ; Pastoriza Abal, Pilar ; Molina-Martínez, I.T. ; Herrero-Vanrell, R. | 2016-12Efficient treatment of ocular diseases can be achieved thanks to the proper use of ophthalmic formulations based on emerging pharmaceutical approaches. Among them, microtechnology and nanotechnology strategies are of great interest in the develo[...]texto impreso
García-Caballero, Cristina ; Prieto-Calvo, Esther ; Checa-Casalengua, Patricia ; García-Martín, Elena ; Polo-Llorens, Vicente ; García-Feijoo, Julián ; Molina-Martínez, Irene Teresa ; Bravo-Osuna, Irene ; Herrero-Vanrell, Rocio | Elsevier | 2017-05-30Local long-term delivery of glial cell line derived neurotrophic factor (GDNF) from vitamin E/poly-lactic-co-glycolic acid microspheres (MSs) protects retinal ganglion cells in an animal model of glaucoma for up to 11 weeks. However, the pharmac[...]texto impreso
Herrero-Vanrell, Rocio ; Bravo-Osuna, Irene ; Andrés-Guerrero, Vanessa ; Vicario-de-la-Torre, Marta ; Molina-Martínez, Irene Teresa | Elsevier | 2014-09Pathologies affecting the posterior segment are one of the major causes of blindness in developed countries and are becoming more prevalent due to the increase in society longevity. Sucessful therapy of diseases affecting the back of the eye req[...]texto impreso
Zhao, Min ; Rodríguez Villagra, Esther ; Kowalczuk, Laura ; Le Normand, Manon ; Berdugo, Marianne ; Levy-Boukris, Rinath ; El Zaoui, Ikram ; Kaufmann, Béatrice ; Gurny, Robert ; Bravo-Osuna, Irene ; Molina-Martínez, Irene T. ; Herrero-Vanrell, Rocio ; Behar-Cohen, Francine | Elsevier | 2017-11-28Mineralocorticoid receptor (MR)contributes to retinal/choroidal homeostasis. Excess MR activation has been shown to be involved in pathogenesis of central serous chorioretinopathy (CSCR). Systemic administration of MR antagonist (MRA) reduces su[...]
