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Título:
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Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study
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Autores:
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López Cuenca, Inés ;
Hoz Montañana, Rosa de ;
García Martín, Elena Salobrar ;
Elvira Hurtado, Lorena ;
Rojas Lozano, Pilar ;
Fernández Albarral, José Antonio ;
Barabash, Ana ;
Salazar Corral, Juan José ;
Ramírez Sebastián, Ana Isabel ;
Ramirez Sebastian, Jose Manuel
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Tipo de documento:
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texto impreso
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Editorial:
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MDPI, 2020-06-03
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Genética médica
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Materia = Ciencias Biomédicas: Medicina: Neurociencias
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Materia = Ciencias Biomédicas: Medicina: Oftalmología
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Tipo = Artículo
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Resumen:
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In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer’s disease (AD). Thirty-five subjects with a family history of Alzheimer disease (AD) (FH+) and ApoE ?4 carriers and 29 age-matched control subjects without a family history of AD (FH?) and ApoE ?4 non-carriers were included. Compared to FH? ApoE ?4 non-carriers, in FH+ ApoE ?4 carriers, there were statistically significant decreases (p
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En línea:
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https://eprints.ucm.es/id/eprint/60836/1/Salazar_2020_jcm-09-01728.pdf
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