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Título:
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When will my mouse die? Life span prediction based on immune function, redox and behavioural parameters in female mice at the adult age
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Autores:
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Martínez de Toda Cabeza, Irene ;
Vida, Carmen ;
Sanz San Miguel, Luis ;
Fuente del Rey, Mónica de la
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2019-09
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/restrictedAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Biología: Fisiología animal
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Tipo = Artículo
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Resumen:
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The identification of predictive markers of life span would help to unravel the underlying mechanisms influencing ageing and longevity. For this aim, 30 variables including immune functions, inflammatory-oxidative stress state and behavioural characteristics were investigated in ICR-CD1 female mice at the adult age (N?=?38). Mice were monitored individually until they died and individual life spans were registered. Multiple linear regression was carried out to construct an Immunity model (adjusted R2?=?75.8%) comprising Macrophage chemotaxis and phagocytosis and Lymphoproliferation capacity, a Redox model (adjusted R2?=?84.4%) involving Reduced Glutathione and Malondialdehyde concentrations and Glutathione Peroxidase activity and a Behavioural model (adjusted R2?=?79.8%) comprising Internal Locomotion and Time spent in open arms indices. In addition, a Combined model (adjusted R2?=?92.4%) and an Immunity-Redox model (adjusted R2?=?88.7%) were also constructed by combining the above-mentioned selected variables. The models were also cross-validated using two different sets of female mice (N?=?30; N?=?40). Correlation between predicted and observed life span was 0.849 (P?0.000) for the Immunity model, 0.691 (P?0.000) for the Redox, 0.662 (P?0.000) for the Behavioural and 0.840 (P?0.000) for the Immunity-Redox model. Thus, these results provide a new perspective on the use of immune function, redox and behavioural markers as prognostic tools in ageing research.
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En línea:
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https://eprints.ucm.es/57567/1/Mart%C3%ADnez%20de%20Toda%2C%20I.%20et%20al.%202019.%20When%20will%20my%20mouse...pdf
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