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Título:
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Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes
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Autores:
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Reche, Pedro A ;
Keskin, Derin B ;
Hussey, Rebecca E ;
Ancuta, Petronela ;
Gabuzda, Dana ;
Reinherz, Ellis L
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Tipo de documento:
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texto impreso
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Editorial:
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BioMed Central, 2006
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Inmunología
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Materia = Ciencias Biomédicas: Biología: Microbiología
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Materia = Ciencias Biomédicas: Biología: Biología molecular
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Materia = Ciencias: Informática: Bioinformática
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Tipo = Artículo
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Resumen:
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Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that maintain sequence conservation. By combining HLA binding predictions with knowledge concerning HLA allele frequencies, a metric estimating population protection coverage (PPC) was computed and epitope pools assembled. Strikingly, only a minority of immunocompetent HIV-1 infected individuals responds to pools with PPC >95%. In contrast, virus-naive individuals uniformly expand IFNgamma producing cells and mount anti-HIV-1 cytolytic activity. This disparity suggests a vaccine design paradigm shift from infected to normal subjects.
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En línea:
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https://eprints.ucm.es/id/eprint/9327/1/31.Reche_etal_MI_2006.pdf
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