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Título:
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Diadenosine tetraphosphate improves adrenergic anti-glaucomatous drug delivery and efficiency
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Autores:
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Loma Lozano, Patricia ;
Guzmán Aránguez, Ana Isabel ;
Pérez de Lara, María Jesús ;
Pintor, Jesús
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2015-05
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/restrictedAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Microbiología médica
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Materia = Ciencias Biomédicas: Medicina: Oftalmología
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Materia = Ciencias Biomédicas: Farmacia: Farmacología
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Tipo = Artículo
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Resumen:
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The effect of the dinucleotide P1, P4-Di (adenosine-5') tetraphosphate (Ap4A) in improving adrenergic anti-glaucomatous delivery by modifying the tight junction proteins of the corneal epithelium was evaluated. Stratified human corneal epithelial cells (HCLE) were treated with Ap4A (100?M) for 5min and TJ protein levels and barrier function were analysed by western blotting and transepithelial electrical resistance (TEER), respectively. Western blot experiments showed a significantreduction at 2h (45% reduction of ZO-1 and 65% reduction of occludin protein levels) as compared to non-treated (control) cells. Two hours after Ap4A treatment, TEER values were significantly reduced (65% as compared to control levels (p
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En línea:
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https://eprints.ucm.es/41000/1/diadenosine%20tetraphosphate-ExpEyeRes2015.pdf
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