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Título:
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Proton Environments in Biomimetic Calcium PhosphatesFormed from Mesoporous Bioactive CaO-SiO2-P2O5 Glasses in vitro: Insights from Solid-State NMR
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Autores:
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Mathew, Renny ;
Turdean-Ionescu, Claudia ;
Yu, Yang ;
Stevensson, Baltzar ;
Izquierdo-Barba, Isabel ;
García Fontecha, Ana ;
Arcos Navarrete, Daniel ;
Vallet Regí, María ;
Eden, Mattias
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Tipo de documento:
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texto impreso
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Editorial:
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American Chemical Society, 2017-05-23
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = En prensa
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Materia = Ciencias Biomédicas: Farmacia: Química inorgánica
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Tipo = Artículo
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Resumen:
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When exposed to body fluids, mesoporous bioactive glasses (MBGs) of the CaO{SiO2{P2O5 system develop a bone-bonding surface layer that initially consists of amorphous calcium phosphate(ACP), which transforms into hydroxy-carbonate apatite (HCA) with a very similar composition as bone/dentin mineral. Information from various 1H-based solid-state nuclear magnetic resonance (NMR) experiments were combined to elucidate the evolution of the proton speciations both at the MBG surface and within each ACP/HCA constituent of the biomimetic phosphate layer formed when each of three MBGs with distinct Ca, Si, and P contents was immersed in a simulated body fluid (SBF) for variable periods between 15 min and 30 days. Directly excited magic-angle-spinning (MAS) 1H NMR spectra mainly reflect the MBG component, whose surface is rich in water and silanol (SiOH) moieties. Double-quantum{single-quantum correlation 1H NMR experimentation at fast MAS revealed their interatomic proximities. The comparatively minor H species of each ACP and HCA component were probed selectively by heteronuclear 1H{31P NMR experimentation. The initially prevailing ACP phase comprises H2O and "non-apatitic" HPO2.
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En línea:
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https://eprints.ucm.es/id/eprint/43067/1/22_201705_MVR_Proton%20Environments%20in%20Biomimetic%20Calcium%20Phosphates%20%28PARA%20REPOSITORIO%29.pdf
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